Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shi Jiazhuang, China.
Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shi Jiazhuang, China.
Biosci Rep. 2019 Mar 28;39(3). doi: 10.1042/BSR20181668. Print 2019 Mar 29.
, having been found expressing differently in liver tissues in our previous work, including and , which are structural homologs named and Recent studies have indicated that involved in the development and proliferation of HepG2 cell, and may be associated with tumor susceptibility. Based on this, we tested the effects of and single-nucleotide polymorphisms for all major Hepatitis B virus (HBV) outcomes and lamivudine (LAM) treatment in Han Chinese. A total of 1649 samples were enrolled, and peripheral blood samples were collected in the present study. The single-nucleotide polymorphisms in the and region were genotyped using MALDI-TOF MS. Our study demonstrated there was no obvious relevance of either -rs33635 or -rs974285 polymorphisms with HBV susceptibility, spontaneous recovery, and development of HBV-related diseases. However, we showed for the first time to our knowledge that -rs33635C was a predictor for LAM therapy (viral response: odds ratio (OR) = 2.436, =0.022; biochemical response: OR = 3.328, =1.73 × 10). These findings might provide potential implications for therapeutic guidance.
先前的研究发现，在肝组织中表达不同，包括和，它们是结构同源物，分别命名为和。最近的研究表明，参与 HepG2 细胞的发育和增殖，而可能与肿瘤易感性有关。基于此，我们检测了和单核苷酸多态性对所有主要乙型肝炎病毒 (HBV) 结局和拉米夫定 (LAM) 治疗在汉族人群中的影响。共纳入 1649 例样本，并在本研究中采集外周血样本。使用 MALDI-TOF MS 对和区域的单核苷酸多态性进行基因分型。我们的研究表明，-rs33635 或 -rs974285 多态性与 HBV 易感性、自发恢复和 HBV 相关疾病的发展均无明显相关性。然而，我们首次表明，-rs33635C 是 LAM 治疗的预测因子（病毒反应：优势比 (OR) = 2.436，=0.022；生化反应：OR = 3.328，=1.73×10）。这些发现可能为治疗指导提供潜在的意义。
