Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense DK-5000, Denmark.
Contact Dermatitis. 2013 May;68(5):277-85. doi: 10.1111/cod.12035.
An association between Compositae sensitization and atopic dermatitis has been suggested on the basis of case reports and clinical studies.
To describe the characteristics of sensitization in Compositae-allergic patients with current and/or past atopic dermatitis.
PATIENTS/MATERIALS/METHODS: Consecutive Compositae-sensitive patients were selected for analysis if they had a history of (i) present and/or past atopic dermatitis or (ii) childhood flexural eczema or (iii) childhood eczema of any kind and a positive prick test result.
Fifty-one persons (35 females and 16 males) were included. The mean age was lower and the percentage of males was slightly higher than in non-atopics. Testing with sesquiterpene lactone mix, parthenolide and Compositae mix 6% or 5% detected 96% of the patients. Occupational sensitization occurred in 22%. The sensitizing pattern did not differ much from that of non-atopics, except that dandelion was an important allergen in children. Cobalt allergy was the most frequent other contact allergy, occurring in 37%.
Persons with current or past atopic dermatitis may become sensitized to Compositae at any age, both occupationally and non-occupationally. They should be screened for Compositae allergy on equal terms with non-atopics, except that dandelion extract should always be tested in children. Co-sensitization to cobalt was frequent, but probably not related to the plant allergy.
基于病例报告和临床研究，提示过敏症与特应性皮炎之间存在联系。
描述 Compositae 过敏患者当前和/或过去特应性皮炎的致敏特征。
患者/材料/方法：如果连续 Compositae 敏感患者具有以下病史，则选择进行分析：（i）当前和/或过去特应性皮炎或（ii）儿童屈侧湿疹或（iii）任何类型的儿童湿疹和阳性划痕试验结果。
共纳入 51 名患者（35 名女性和 16 名男性）。平均年龄较低，男性比例略高于非特应性患者。用倍半萜内酯混合物、小白菊内酯和 6%或 5%的 Compositae 混合物进行测试可检测出 96%的患者。职业性致敏占 22%。致敏模式与非特应性患者差异不大，只是蒲公英在儿童中是一种重要的过敏原。钴过敏是最常见的其他接触性过敏，发生率为 37%。
当前或过去患有特应性皮炎的患者可能会在任何年龄因职业和非职业原因对 Compositae 过敏。除了应该在儿童中始终测试蒲公英提取物外，他们应与非特应性患者平等地进行 Compositae 过敏筛查。钴的共致敏很常见，但可能与植物过敏无关。
