Kanerva L, Estlander T, Alanko K, Jolanki R
Section of Dermatology, Finnish Institute of Occupational Health, Helsinki, Finland.
Am J Contact Dermat. 2001 Mar;12(1):18-24. doi: 10.1053/ajcd.2000.9547.
Compositae mix and sesquiterpene-lactone (SL) mix are important patch test substances to show allergic contact dermatitis from various Compositae plants.
The aims of this study are to calculate the sensitization rates to Compositae mix and SL mix in an occupational dermatology clinic and to describe cases of active sensitization caused by patch testing with Compositae mix and SL mix.
Conventional patch testing was performed. SL mix (0.1%) and Compositae mix (6% in petrolatum) were tested in a modified European standard series and a plant allergen series. Testing with other appropriate patch test series was also performed.
SL mix provoked 8 allergic patch test reactions (0.7%) in 1,076 patients, whereas Compositae mix was positive in 15 of 346 patients (4.2%). Three patients were actively sensitized to Compositae mix and 1 patient to SL mix. One patient was also sensitized to other plant allergens in a series of allergenic plant chemicals, namely to Mansonone A, an ortho-quinone; (R)-3,4-dimethoxydalbergione, a quinone; and Chlorophorin, a hydroxy stilbene. Allergic patch test reactions to laurel leaf were caused by cross-sensitization to SLs.
Compositae mix seems to be a more important patch test substance than SL mix to detect allergic contact dermatitis to Compositae plants, but patch testing may sensitize. The concentration of the individual components of the Compositae mix should be adjusted so that the mix detects allergic patients but does not sensitize.
菊科混合物和倍半萜内酯(SL)混合物是用于显示各种菊科植物引起的过敏性接触性皮炎的重要斑贴试验物质。
本研究的目的是计算职业皮肤科诊所中对菊科混合物和SL混合物的致敏率,并描述菊科混合物和SL混合物斑贴试验引起的主动致敏病例。
进行常规斑贴试验。在改良的欧洲标准系列和植物过敏原系列中测试SL混合物(0.1%)和菊科混合物(凡士林基质中6%)。也使用其他合适的斑贴试验系列进行测试。
SL混合物在1076例患者中引发了8例过敏性斑贴试验反应(0.7%),而菊科混合物在346例患者中的15例呈阳性(4.2%)。3例患者对菊科混合物主动致敏,1例患者对SL混合物主动致敏。1例患者还对一系列致敏植物化学物质中的其他植物过敏原致敏,即对邻醌曼宋酮A、醌(R)-3,4-二甲氧基黄檀醌和羟基芪氯酚致敏。对月桂叶的过敏性斑贴试验反应是由对SLs的交叉致敏引起的。
对于检测菊科植物引起的过敏性接触性皮炎,菊科混合物似乎是比SL混合物更重要的斑贴试验物质,但斑贴试验可能会导致致敏。应调整菊科混合物各成分的浓度,以便该混合物能检测出过敏患者,但又不会引起致敏。