Departamento de Psicobiología, Facultad de Psicología, Universidad Complutense, Madrid, Spain.
Vitam Horm. 2013;92:165-96. doi: 10.1016/B978-0-12-410473-0.00007-6.
The endocannabinoid system functions as a potent regulator of feeding behavior and energy balance through complex central and peripheral mechanisms. Recent findings have demonstrated the existence of cooperation between peripheral cannabinoid CB1 receptors and the satiety hormone cholecystokinin (CCK). The two systems have opposing actions in the modulation of feeding: while endocannabinoids such as anandamide promote feeding, CCK controls gastrointestinal motility and appetite suppression. In this review, we examine the individual contribution of endocannabinoids and CCK in the modulation of appetite and explore the interaction between the two systems. We also highlight the potential benefits of simultaneously targeting peripheral CB1 and CCK1 receptors to design new therapies to fight obesity.
内源性大麻素系统通过复杂的中枢和外周机制发挥作用，是调节摄食行为和能量平衡的强大调节因子。最近的研究结果表明，外周大麻素 CB1 受体和饱腹感激素胆囊收缩素 (CCK) 之间存在合作。这两个系统在调节摄食方面的作用相反：内源性大麻素，如花生四烯酸乙醇胺，促进摄食，而 CCK 则控制胃肠道蠕动和食欲抑制。在这篇综述中，我们检查了内源性大麻素和 CCK 在调节食欲方面的单独作用，并探讨了这两个系统之间的相互作用。我们还强调了同时针对外周 CB1 和 CCK1 受体的潜在益处，以设计新的治疗肥胖症的方法。
