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重新评估高频振荡通气治疗急性呼吸窘迫综合征：靶向治疗方法会成功吗？

Re-evaluating high-frequency oscillation for ARDS: Would a targeted approach be successful?

作者信息

Goligher Ewan C, Ferguson Niall D

出版信息

Crit Care. 2013 Apr 19;17(2):133. doi: 10.1186/cc12602.

DOI:10.1186/cc12602
PMID:23601696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3672488/
Abstract

High-frequency oscillatory ventilation (HFOV) seems ideal for lung protection in acute respiratory distress syndrome, but randomized trials have not shown a mortality reduction. The initial oxygenation response to HFOV appears to be associated with survival. Here, we discuss the mechanisms of oxygenation response to increases in airway pressure and the interpretation of the oxygenation response observed in the present study.

摘要

高频振荡通气（HFOV）似乎是急性呼吸窘迫综合征肺保护的理想方法，但随机试验并未显示其能降低死亡率。HFOV的初始氧合反应似乎与生存率相关。在此，我们讨论气道压力增加时氧合反应的机制以及本研究中观察到的氧合反应的解读。

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Physiological predictors of survival during high-frequency oscillatory ventilation in adults with acute respiratory distress syndrome.急性呼吸窘迫综合征成人患者高频振荡通气期间生存的生理预测指标
Crit Care. 2013 Mar 4;17(2):R40. doi: 10.1186/cc12550.
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High-frequency oscillatory ventilation on shaky ground.不稳定状态下的高频振荡通气
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High-frequency oscillation for acute respiratory distress syndrome.高频振荡治疗急性呼吸窘迫综合征。
N Engl J Med. 2013 Feb 28;368(9):806-13. doi: 10.1056/NEJMoa1215716. Epub 2013 Jan 22.
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Point: High-frequency ventilation is the optimal physiological approach to ventilate ARDS patients.观点：高频通气是对急性呼吸窘迫综合征患者进行通气的最佳生理学方法。
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