Van Damme H, Dekoster G, Creemers E, Hermans G, Limet R
Cardiovascular Surgery Department, University Hospital Sart-Tilman, Liège, Belgium.
Surgery. 1990 Jul;108(1):105-9.
We report two recent observations of giant hemangiopericytoma of the lung, one in a 4-year-old child and another in a 65-year-old man. There were no specific clinical signs, but the radiologic appearance was rather characteristic in both cases, as were the histologic findings. Pneumonectomy was carried out, complicated in each case by rupture of the fragile, incomplete pseudocapsule and diffuse dissemination of necrotic tumor tissue in the operative field and opposite bronchial tree. Outcome was fatal in both cases within a few months, with extensive, rapidly growing metastases in the subcutaneous scar tissue of the thoracotomy and in the other lung and in one case with diffuse diaphragmatic and intraabdominal metastases. These two observations will offer some guidelines for better understanding of this rare localization of hemangiopericytoma, its natural history, and its optimal treatment, with special reference to the malignant potential and local recurrence rate.
我们报告了两例近期观察到的肺部巨大血管外皮细胞瘤，一例发生在一名4岁儿童身上，另一例发生在一名65岁男性身上。两例均无特异性临床症状，但放射学表现颇具特征性，组织学检查结果亦是如此。两例均实施了肺切除术，术中均出现了脆弱、不完整假包膜破裂的情况，坏死肿瘤组织在术野及对侧支气管树中弥漫播散。两例患者均在数月内死亡，开胸手术切口皮下瘢痕组织、另一肺叶出现广泛且迅速生长的转移灶，其中一例还伴有膈肌及腹腔内弥漫性转移。这两例观察结果将为更好地理解血管外皮细胞瘤这种罕见的发病部位、其自然病程及其最佳治疗方法提供一些指导，尤其涉及恶性潜能和局部复发率。
