Institute of Pathology, Helios Clinics, Gauting, Germany.
Institute of Pathology, Mittelthueringen, Bad Berka, Germany.
Virchows Arch. 2021 May;478(5):841-849. doi: 10.1007/s00428-020-02972-9. Epub 2020 Nov 26.
Two cases of myopericytosis combined with pericytoma originating within the lung are reported. These are rare pulmonary tumors. The differential diagnosis for hemangiopericytoma and pericytic tumors with glomus elements is discussed. Both myopericytic lesions mimic other lesions, which are more commonly seen in the lung. Based on the expression of vascular growth factor receptors 2 and 3, an antiangiogenic therapy was suggested for the patient with the myopericytoma. A treatment with an angiogenesis inhibitor resulted in a regression of the tumor, but not the precursor lesion. Probably a more specific therapy using tyrosine kinase inhibitors for VEGFR2/3 might better control these myopericytic proliferations.
报告了两例起源于肺的肌纤维母细胞瘤合并血管外皮细胞瘤。这些是罕见的肺肿瘤。讨论了血管外皮细胞瘤和具有颗粒体成分的血管周细胞瘤的鉴别诊断。两种肌纤维母细胞病变都类似于更常见于肺部的其他病变。基于血管生长因子受体 2 和 3 的表达，建议对肌纤维母细胞瘤患者进行抗血管生成治疗。血管生成抑制剂的治疗导致肿瘤消退，但前体病变没有消退。可能使用针对 VEGFR2/3 的酪氨酸激酶抑制剂进行更特异的治疗可能会更好地控制这些肌纤维母细胞增殖。
