硬骨鱼的基因型性别决定：来自睾丸决定基因amhy的见解。

Genotypic sex determination in teleosts: insights from the testis-determining amhy gene.

作者信息

Hattori Ricardo Shohei, Strüssmann Carlos Augusto, Fernandino Juan Ignacio, Somoza Gustavo Manuel

机构信息

Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7 Minato, Tokyo, Japan.

出版信息

Gen Comp Endocrinol. 2013 Oct 1;192:55-9. doi: 10.1016/j.ygcen.2013.03.019. Epub 2013 Apr 16.

DOI:10.1016/j.ygcen.2013.03.019

PMID:23602719

Abstract

The master sex-determining genes identified so far in fishes are clearly not conserved, as evidenced by several unrelated genes reported to play critical roles in sex determination. In this study, we reviewed the molecular process of sex determination in the Patagonian pejerrey Odontesthes hatcheri, an emerging model due to the recent discovery that a Y-chromosome linked, duplicated copy of the anti-Müllerian hormone gene, amhy plays a pivotal role in sex determination. A comparative analysis with other newly found sex-determining genes of teleost fish, DMY/dmrt1bY, sdY, amhr2, and gsdf(Y) is performed and alternative ideas are proposed to explain the mechanism involved in the rise of various types of non-homologous sex-determining genes.

摘要

迄今为止，在鱼类中鉴定出的主要性别决定基因显然并不保守，这一点已由多个据报道在性别决定中起关键作用的不相关基因所证明。在本研究中，我们回顾了巴塔哥尼亚银汉鱼（Odontesthes hatcheri）性别决定的分子过程，这种鱼因最近发现Y染色体连锁的抗缪勒氏管激素基因（amhy）的重复拷贝在性别决定中起关键作用而成为一个新兴模型。我们进行了与其他新发现的硬骨鱼性别决定基因（DMY/dmrt1bY、sdY、amhr2和gsdf(Y)）的比较分析，并提出了其他观点来解释各种类型的非同源性别决定基因产生的机制。