Cross Cancer Institute, Medical Physics Department, 11560 University Ave, Edmonton, Alberta T6G 1Z2, Canada.
Adv Drug Deliv Rev. 2013 Jul;65(8):1056-64. doi: 10.1016/j.addr.2013.04.010. Epub 2013 Apr 18.
Magnetic resonance (MR) studies of the therapeutic efficacy of fluorinated drugs have recently become possible due to improvements in detection including the application of very strong magnetic fields up to 9.4Tesla (T). These advances allow tracking, identification, and quantification of (19)F-labeled biopharmaceuticals using (19)F MR imaging ((19)F MRI) and spectroscopy ((19)F MRS). Both techniques are noninvasive, are nondestructive, and enable serial measurements. They also allow for controlled and systematic studies of cellular metabolism in cancerous tissue in vivo (small animals and humans) and in vitro (body fluids, cells culture, tissue extracts and isolated tissues). Here we provide an overview of the (19)F MRI and (19)F MRS techniques used for tracking (19)F labeled anticancer chemotherapeutics and antibodies which allow quantification of drug uptake in cancer cells in vitro.
由于检测技术的改进，包括高达 9.4 特斯拉（T）的超强磁场的应用，最近已经可以对氟代药物的治疗效果进行磁共振（MR）研究。这些进展使得可以使用（19）F 磁共振成像（（19）F MRI）和光谱学（（19）F MRS）对（19）F 标记的生物制药进行跟踪、识别和定量。这两种技术都是非侵入性的、无损的，可以进行连续测量。它们还允许在体内（小动物和人类）和体外（体液、细胞培养物、组织提取物和分离组织）对癌组织中的细胞代谢进行受控和系统的研究。在这里，我们提供了用于跟踪（19）F 标记的抗癌化疗药物和抗体的（19）F MRI 和（19）F MRS 技术的概述，这些技术允许定量测定体外癌细胞对药物的摄取。
Adv Drug Deliv Rev. 2013-4-18
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012-2-21
Magn Reson Med. 2007-10
Nat Biotechnol. 2005-8
Crit Rev Oncol Hematol. 2005-12
Zotero 插件