[大鼠出生后早期个体发育过程中视网膜和大脑的脂质过氧化系统]
[The lipid peroxidation system in the retina and brain of rats during early postnatal ontogeny].
作者信息
Efimova M G
出版信息
Zh Evol Biokhim Fiziol. 1990 Jan-Feb;26(1):130-3.
The content of the lipid peroxidation products in the rat retina and brain tissues during the early postnatal period (20-45 day of life) was estimated. It was shown during this period the content of conjugated dienes was decreased: the content of malondialdehyde and Schiff bases was without changes in the rat retina. At the same time the content of the conjugated dienes and Schiff bases in the brain tissue was proportionally increased. The activity of glutathioneperoxidase and glutathionereductase was decreased in the retina and not changed in brain. In the same period of the life the content of alpha-tocopherol in the retina was increased. We observed also the enhance of the rate of the induced lipid peroxidation in brain and retina of older animals.
对出生后早期（出生后20 - 45天）大鼠视网膜和脑组织中脂质过氧化产物的含量进行了评估。结果显示，在此期间，共轭二烯的含量降低：大鼠视网膜中丙二醛和席夫碱的含量没有变化。与此同时，脑组织中共轭二烯和席夫碱的含量成比例增加。视网膜中谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性降低，而脑组织中则没有变化。在同一时期，视网膜中α - 生育酚的含量增加。我们还观察到老年动物脑和视网膜中诱导脂质过氧化速率的提高。
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