Department of Neonatology, University Children's Hospital, Tuebingen, Germany.
Arch Dis Child Fetal Neonatal Ed. 2013 Sep;98(5):F430-3. doi: 10.1136/archdischild-2012-303384. Epub 2013 Apr 19.
Long-term follow-up data on preterm infants with breast milk-acquired postnatal cytomegalovirus (CMV) infection are sparse.
To systematically evaluate the long-term cognitive outcome and prevalence of cerebral palsy (CP) in patients after postnatal CMV infection.
All surviving infants <1500 g born in our centre between 1 June 1995 and 1 June 2000, and with postnatal CMV infection acquired at up to 3 months of corrected age, were eligible for our study; this included neurological and neurocognitive assessment, using the Kaufman Assessment Battery for Children (K-ABC) at the age of >4 years. A blinded and controlled matched-pairs design was used with gestational age, gender and date of birth as matching criteria.
Of 50 eligible children, 42 (84%) could be tested. There was no difference in the prevalence of cerebral palsy. Following CMV infection during their hospital stay, infants had significantly lower results in the simultaneous processing scale of the K-ABC (p=0.029) after correction for additional risk factors like socioeconomic status (SES). Results for the sequential and achievement scales were only slightly reduced (p>0.05).
It seems possible that breast milk-acquired CMV infection has a detrimental influence on cognitive development of preterm infants.
关于母乳喂养的早产儿后天获得性巨细胞病毒（CMV）感染的长期随访数据很少。
系统评估后天性 CMV 感染后患者的长期认知结局和脑瘫（CP）发生率。
1995 年 6 月 1 日至 2000 年 6 月 1 日期间在我们中心出生、体重<1500 克且在纠正年龄达 3 个月时获得后天性 CMV 感染的所有存活婴儿有资格参加我们的研究；包括神经学和神经认知评估，使用 Kaufman 儿童评估量表（K-ABC）在>4 岁时进行。采用盲法和对照配对设计，以胎龄、性别和出生日期为匹配标准。
50 名符合条件的儿童中，有 42 名（84%）可进行测试。脑瘫的发生率没有差异。在住院期间感染 CMV 后，校正社会经济状况（SES）等额外风险因素后，婴儿在 K-ABC 的同时处理量表中的得分明显较低（p=0.029）。顺序和成就量表的结果仅略有降低（p>0.05）。
母乳喂养的 CMV 感染似乎对早产儿的认知发育有不利影响。
