自噬在缺血预处理中的保护作用。
The protective roles of autophagy in ischemic preconditioning.
机构信息
Department of Anesthesiology, Gansu Provincial Hospital, Lanzhou 730000, China.
出版信息
Acta Pharmacol Sin. 2013 May;34(5):636-43. doi: 10.1038/aps.2013.18. Epub 2013 Apr 22.
Abstract
Autophagy, a process for the degradation of protein aggregates and dysfunctional organelles, is required for cellular homeostasis and cell survival in response to stress and is implicated in endogenous protection. Ischemic preconditioning is a brief and nonlethal episode of ischemia, confers protection against subsequent ischemia-reperfusion through the up-regulation of endogenous protective mechanisms. Emerging evidence shows that autophagy is associated with the protective effect of ischemic preconditioning. This review summarizes recent progress in research on the functions and regulations of the autophagy pathway in preconditioning-induced protection and cellular survival.
摘要
自噬是一种降解蛋白质聚集体和功能失调细胞器的过程，对于细胞内环境稳定和细胞在应激条件下的存活是必需的，并且与内源性保护有关。缺血预处理是一种短暂的、非致死性的缺血期，通过上调内源性保护机制来对抗随后的缺血再灌注损伤。新出现的证据表明，自噬与缺血预处理的保护作用有关。这篇综述总结了自噬途径在预处理诱导的保护和细胞存活中的作用和调节的最新研究进展。
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