Kim J H, Guimaraes P O, Shen M Y, Masukawa L M, Spencer D D
Section of Neuropathology, Yale University School of Medicine, New Haven, CT 06510.
Acta Neuropathol. 1990;80(1):41-5. doi: 10.1007/BF00294220.
The majority of patients with temporal lobe epilepsy show hippocampal sclerosis, which pathologically represents neuronal loss and gliosis. We studied volumetric neuronal density on a representative mid to mid-posterior level slice of hippocampi surgically removed from intractable temporal lobe epilepsy cases, and compared the results between 25 non-tumor epilepsy (NTE) cases and 5 tumor-associated epilepsy (TAE) cases. Eleven age-matched non-epileptic autopsy cases were studied as controls. Cells were counted in the CA1 through CA4 fields and the stratum granulosum of the dentate fascia. In NTE every hippocampal field showed statistically significant loss of neurons, the neuronal density in each field ranging from 35% to 50% of that of control. The mean neuronal density between the TAE and NTE groups also showed statistically significant differences in all hippocampal fields. The neuronal density of hippocampal fields of NTE ranged from 43% to 58% of that of TAE. Tumor-associated epilepsy cases, however, failed to show any statistically significant deviation from the control in their neuronal density. The etiology of the difference in neuronal density between the TAE and NTE groups is discussed.
大多数颞叶癫痫患者表现出海马硬化，其病理特征为神经元丢失和胶质增生。我们研究了从难治性颞叶癫痫病例中手术切除的海马代表性中至中后层面切片上的体积神经元密度，并比较了25例非肿瘤性癫痫（NTE）病例和5例肿瘤相关性癫痫（TAE）病例的结果。选取11例年龄匹配的非癫痫尸检病例作为对照。对CA1至CA4区以及齿状回颗粒层的细胞进行计数。在NTE中，每个海马区均显示出具有统计学意义的神经元丢失，每个区域的神经元密度为对照组的35%至50%。TAE组和NTE组之间的平均神经元密度在所有海马区也显示出统计学差异。NTE海马区的神经元密度为TAE的43%至58%。然而，肿瘤相关性癫痫病例的神经元密度与对照组相比未显示出任何具有统计学意义的偏差。本文讨论了TAE组和NTE组之间神经元密度差异的病因。
