Pieri C
Age (Omaha). 1997 Apr;20(2):71-9. doi: 10.1007/s11357-997-0007-z.
Food restriction (FR) is a well-recognized method of extending mean and maximum longevity of rodents, but the mode of its action remains to be uncovered. This article reviews the effect of FR on the physical-chemical properties and lipid peroxidizability of cellular membranes. FR prevents the age-dependent increase in microviscosity and peroxidizability of cellular membranes. It has been suggested that a decrease in the body temperature occurring in undernourished animals may play a fundamental role in the process. Indeed, the lowering of average body temperature occurring in FR animals may induce a modification in membrane lipid composition, stimulating the cells to counteract the rigidifying effect of lower temperature. Thus, membranes are maintained in a proper functional state by a mechanism similar to that found in poikilotherm animals.
食物限制（FR）是一种公认的延长啮齿动物平均寿命和最大寿命的方法，但其作用方式仍有待揭示。本文综述了食物限制对细胞膜物理化学性质和脂质过氧化能力的影响。食物限制可防止细胞膜微粘度和过氧化能力随年龄增长而增加。有人认为，营养不良动物体温的降低可能在这一过程中起根本作用。事实上，食物限制动物平均体温的降低可能会引起膜脂质组成的改变，刺激细胞对抗较低温度的硬化作用。因此，细胞膜通过一种类似于变温动物的机制维持在适当的功能状态。
