发育、衰老及基因调控中的氧化应激与超氧化物歧化酶
Oxidative stress and superoxide dismutase in development, aging and gene regulation.
作者信息
Allen R G
出版信息
Age (Omaha). 1998 Apr;21(2):47-76. doi: 10.1007/s11357-998-0007-7.
Abstract
Free radicals and other reactive oxygen species are produced in the metabolic pathways of aerobic cells and affect a number of biological processes. Oxidation reactions have been postulated to play a role in aging, a number of degenerative diseases, differentiation and development as well as serving as subcellular messengers in gene regulatory and signal transduction pathways. The discovery of the activity of superoxide dismutase is a seminal work in free radical biology, because it established that free radicals were generated by cells and because it made removal of a specific free radical substance possible for the first time, which greatly accelerated research in this area. In this review, the role of reactive oxygen in aging, amyotrophic lateral sclerosis (a neurodegenerative disease), development, differentiation, and signal transduction are discussed. Emphasis is also given to the role of superoxide dismutases in these phenomena.
摘要
自由基和其他活性氧物质在需氧细胞的代谢途径中产生，并影响许多生物过程。氧化反应被认为在衰老、多种退行性疾病、分化和发育中起作用，并且在基因调控和信号转导途径中作为亚细胞信使。超氧化物歧化酶活性的发现是自由基生物学中的一项开创性工作，因为它证实了细胞能产生自由基，并且首次使得去除一种特定的自由基物质成为可能，这极大地加速了该领域的研究。在这篇综述中，讨论了活性氧在衰老、肌萎缩侧索硬化症（一种神经退行性疾病）、发育、分化和信号转导中的作用。同时也强调了超氧化物歧化酶在这些现象中的作用。
相似文献
1
Oxidative stress and superoxide dismutase in development, aging and gene regulation.发育、衰老及基因调控中的氧化应激与超氧化物歧化酶
Age (Omaha). 1998 Apr;21(2):47-76. doi: 10.1007/s11357-998-0007-7.
3
Oxidative stress and gene regulation.氧化应激与基因调控。
Free Radic Biol Med. 2000 Feb 1;28(3):463-99. doi: 10.1016/s0891-5849(99)00242-7.
4
[Free oxygen radiacals and kidney diseases--part I].[游离氧自由基与肾脏疾病——第一部分]
Med Pregl. 2000 Sep-Oct;53(9-10):463-74.
5
Oxidative stress: the paradox of aerobic life.氧化应激：有氧生命的悖论。
Biochem Soc Symp. 1995;61:1-31. doi: 10.1042/bss0610001.
6
The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids.
FASEB J. 1999 Dec;13(15):2318-28. doi: 10.1096/fasebj.13.15.2318.
7
Expanding roles of superoxide dismutases in cell regulation and cancer.超氧化物歧化酶在细胞调节和癌症中的作用不断扩大。
Drug Discov Today. 2016 Jan;21(1):143-149. doi: 10.1016/j.drudis.2015.10.001. Epub 2015 Oct 19.
8
[Superoxide radical and superoxide dismutase in the free-radical theory of aging (a review)].[衰老自由基理论中的超氧自由基与超氧化物歧化酶（综述）]
Vopr Med Khim. 1982 Jul-Aug;28(4):8-25.
9
Cells from individuals with SOD-1 associated familial amyotrophic lateral sclerosis do not have an increased susceptibility to radiation-induced free radical production or DNA damage.
J Neurol Sci. 1999 Mar 15;164(1):89-92. doi: 10.1016/s0022-510x(99)00053-2.
10
Regulation of superoxide dismutase genes: implications in disease.超氧化物歧化酶基因的调控：在疾病中的意义。
Free Radic Biol Med. 2009 Aug 15;47(4):344-56. doi: 10.1016/j.freeradbiomed.2009.05.018. Epub 2009 May 25.
引用本文的文献
1
The Effects of Radiation Therapy on the Ocular Apparatus: Implications for Management.放射治疗对眼部器官的影响：管理启示
Cancers (Basel). 2025 Aug 8;17(16):2605. doi: 10.3390/cancers17162605.
2
Extracting protein from microalgae () for proteome analysis.从微藻中提取蛋白质用于蛋白质组分析。
MethodsX. 2022 Feb 17;9:101637. doi: 10.1016/j.mex.2022.101637. eCollection 2022.
3
Positive Effect of L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties.L. 草药提取物对皮肤细胞的积极影响及基于大麻素的水凝胶性能评估。
Molecules. 2021 Feb 4;26(4):802. doi: 10.3390/molecules26040802.
4
Cosmetic and Dermatological Properties of Selected Ayurvedic Plant Extracts.某些药用植物提取物的美容和皮肤科特性。
Molecules. 2021 Jan 25;26(3):614. doi: 10.3390/molecules26030614.
5
Effect of Fermentation Time on Antioxidant and Anti-Ageing Properties of Green Coffee Kombucha Ferments.发酵时间对绿咖啡康普茶发酵物抗氧化和抗衰老性能的影响。
Molecules. 2020 Nov 18;25(22):5394. doi: 10.3390/molecules25225394.
6
Traumatic brain injury-induced cerebral microbleeds in the elderly.老年人外伤性脑损伤引起的脑微出血。
Geroscience. 2021 Feb;43(1):125-136. doi: 10.1007/s11357-020-00280-3. Epub 2020 Oct 3.
7
Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial.对氧磷酶1-L55M基因变异与乳腺癌风险的关联：一项病例对照试验。
Asian Pac J Cancer Prev. 2020 Jan 1;21(1):255-258. doi: 10.31557/APJCP.2020.21.1.255.
8
Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells.Csk诱导的Src酪氨酸530磷酸化对于过氧化氢介导的人脐静脉内皮细胞中ERK1/2的抑制至关重要。
Sci Rep. 2015 Aug 3;5:12725. doi: 10.1038/srep12725.
9
Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review.衰老大脑中的氧化应激与抗氧化防御欠佳的遗传标志物：理论综述
Rev Neurosci. 2014;25(6):805-19. doi: 10.1515/revneuro-2014-0046.
10
Effects of oxygen, growth state, and senescence on the antioxidant responses of WI-38 fibroblasts.氧气、生长状态和衰老对WI-38成纤维细胞抗氧化反应的影响。
Age (Dordr). 2010 Dec;32(4):435-49. doi: 10.1007/s11357-010-9149-5. Epub 2010 May 15.
本文引用的文献
1
Physiological dominance and physiological isolation in development and reconstitution.发育与重建中的生理优势和生理隔离
Wilhelm Roux Arch Entwickl Mech Org. 1929 Jun;117(1):21-66. doi: 10.1007/BF02110962.
2
Aging: a theory based on free radical and radiation chemistry.衰老：一种基于自由基与辐射化学的理论。
J Gerontol. 1956 Jul;11(3):298-300. doi: 10.1093/geronj/11.3.298.
3
The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B.过氧化氢和超氧化物作为信使在转录因子NF-κB激活中的作用。
Chem Biol. 1995 Jan;2(1):13-22. doi: 10.1016/1074-5521(95)90076-4.
4
Mitochondrial involvement in the ageing process. Facts and controversies.线粒体与衰老过程。事实与争议。
Mol Cell Biochem. 1997 Sep;174(1-2):325-8.
5
Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress.仓鼠adapt78信使核糖核酸是一种唐氏综合征关键区域同源物，可被氧化应激诱导产生。
Arch Biochem Biophys. 1997 Jun 1;342(1):6-12. doi: 10.1006/abbi.1997.0109.
6
Redox regulation of lipopolysaccharide (LPS)-induced interleukin-8 (IL-8) gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells.脂多糖（LPS）诱导的白细胞介素-8（IL-8）基因表达的氧化还原调节，由人星形细胞瘤U373细胞中的核因子κB（NFκB）和激活蛋白-1（AP-1）介导 。
Biochem Biophys Res Commun. 1997 Mar 17;232(2):568-73. doi: 10.1006/bbrc.1997.6264.
7
Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages.
Biochem Biophys Res Commun. 1997 Mar 6;232(1):33-7. doi: 10.1006/bbrc.1997.6221.
8
Role of oxygen-derived free radicals in free growth retardation induced by ischemia-reperfusion in rats.
Am J Physiol. 1997 Feb;272(2 Pt 2):H701-5. doi: 10.1152/ajpheart.1997.272.2.H701.
9
DNA fragmentation and Prolonged expression of c-fos, c-jun, and hsp70 in kainic acid-induced neuronal cell death in transgenic mice overexpressing human CuZn-superoxide dismutase.在过表达人铜锌超氧化物歧化酶的转基因小鼠中，海藻酸诱导的神经元细胞死亡过程中的DNA片段化以及c-fos、c-jun和hsp70的长期表达。
J Cereb Blood Flow Metab. 1997 Mar;17(3):241-56. doi: 10.1097/00004647-199703000-00001.
10
Mediation by arachidonic acid metabolites of the H2O2-induced stimulation of mitogen-activated protein kinases (extracellular-signal-regulated kinase and c-Jun NH2-terminal kinase).花生四烯酸代谢产物对过氧化氢诱导的丝裂原活化蛋白激酶（细胞外信号调节激酶和c-Jun氨基末端激酶）刺激的介导作用。
Eur J Biochem. 1997 Mar 1;244(2):587-95. doi: 10.1111/j.1432-1033.1997.00587.x.
Zotero 插件