发育、衰老及基因调控中的氧化应激与超氧化物歧化酶
Oxidative stress and superoxide dismutase in development, aging and gene regulation.
作者信息
Allen R G
出版信息
Age (Omaha). 1998 Apr;21(2):47-76. doi: 10.1007/s11357-998-0007-7.
Abstract
Free radicals and other reactive oxygen species are produced in the metabolic pathways of aerobic cells and affect a number of biological processes. Oxidation reactions have been postulated to play a role in aging, a number of degenerative diseases, differentiation and development as well as serving as subcellular messengers in gene regulatory and signal transduction pathways. The discovery of the activity of superoxide dismutase is a seminal work in free radical biology, because it established that free radicals were generated by cells and because it made removal of a specific free radical substance possible for the first time, which greatly accelerated research in this area. In this review, the role of reactive oxygen in aging, amyotrophic lateral sclerosis (a neurodegenerative disease), development, differentiation, and signal transduction are discussed. Emphasis is also given to the role of superoxide dismutases in these phenomena.
摘要
自由基和其他活性氧物质在需氧细胞的代谢途径中产生，并影响许多生物过程。氧化反应被认为在衰老、多种退行性疾病、分化和发育中起作用，并且在基因调控和信号转导途径中作为亚细胞信使。超氧化物歧化酶活性的发现是自由基生物学中的一项开创性工作，因为它证实了细胞能产生自由基，并且首次使得去除一种特定的自由基物质成为可能，这极大地加速了该领域的研究。在这篇综述中，讨论了活性氧在衰老、肌萎缩侧索硬化症（一种神经退行性疾病）、发育、分化和信号转导中的作用。同时也强调了超氧化物歧化酶在这些现象中的作用。
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