Gusev V A, Panchenko L F
Vopr Med Khim. 1982 Jul-Aug;28(4):8-25.
Review is presented on the role of superoxide radicals and other intermediates of single electron reduction of oxygen in aging as well as on geroprotective importance of superoxide dismutase. These factors are considered in relation with age. Significance of direct and indirect methods for estimation of total O2-radicals is analyzed. Possible role of O2-radicals and superoxide dismutase in regulation of cell division and differentiation is also discussed. Life span of cells in peripheric circulation correlates with superoxide dismutase content in these cells and their ability to generate exogenous O2-.
本文综述了超氧自由基及其他氧单电子还原中间体在衰老过程中的作用，以及超氧化物歧化酶的老年保护重要性。这些因素与年龄相关。分析了评估总氧自由基的直接和间接方法的意义。还讨论了氧自由基和超氧化物歧化酶在调节细胞分裂和分化中的可能作用。外周循环中细胞的寿命与这些细胞中超氧化物歧化酶的含量及其产生外源性超氧阴离子的能力相关。
