• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial.对氧磷酶1-L55M基因变异与乳腺癌风险的关联：一项病例对照试验。
Asian Pac J Cancer Prev. 2020 Jan 1;21(1):255-258. doi: 10.31557/APJCP.2020.21.1.255.
2
The MMP-2 -735 C allele is a risk factor for susceptibility to breast cancer.基质金属蛋白酶-2 -735 C等位基因是乳腺癌易感性的一个风险因素。
Asian Pac J Cancer Prev. 2014;15(15):6199-203. doi: 10.7314/apjcp.2014.15.15.6199.
3
Association of L55M and Q192R polymorphisms in paraoxonase 1 (PON1) gene with breast cancer risk and their clinical significance.载脂蛋白 1（PON1）基因 L55M 和 Q192R 多态性与乳腺癌风险的关联及其临床意义。
Mol Cell Biochem. 2011 May;351(1-2):117-23. doi: 10.1007/s11010-011-0718-4. Epub 2011 Jan 13.
4
Association of paraoxonase-1(Q192R and L55M) gene polymorphisms and activity with colorectal cancer and effect of surgical intervention.对氧磷酶-1（Q192R和L55M）基因多态性及活性与结直肠癌的关联以及手术干预的影响
Asian Pac J Cancer Prev. 2015;16(2):803-9. doi: 10.7314/apjcp.2015.16.2.803.
5
A common genetic variation in paraoxonase 1 and risk of breast cancer: a literature review, meta-analysis, and analysis.对氧磷酶1的常见基因变异与乳腺癌风险：文献综述、荟萃分析及分析
Nucleosides Nucleotides Nucleic Acids. 2023;42(1):1-16. doi: 10.1080/15257770.2022.2107216. Epub 2022 Aug 8.
6
Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C allele are risk factors for breast cancer.基质金属蛋白酶-9 -1562T等位基因及其与基质金属蛋白酶-2 -735C等位基因的组合是乳腺癌的危险因素。
Asian Pac J Cancer Prev. 2015;16(3):1175-9. doi: 10.7314/apjcp.2015.16.3.1175.
7
Significant association between ERCC2 and MTHR polymorphisms and breast cancer susceptibility in Moroccan population: genotype and haplotype analysis in a case-control study.在摩洛哥人群中，ERCC2 和 MTHR 多态性与乳腺癌易感性之间存在显著关联：病例对照研究中的基因型和单倍型分析。
BMC Cancer. 2018 Mar 15;18(1):292. doi: 10.1186/s12885-018-4214-z.
8
PON1 L55M polymorphism might contribute to the risk of cancer.对氧磷酶1（PON1）L55M多态性可能会增加患癌风险。
Panminerva Med. 2017 Mar;59(1):107-113. doi: 10.23736/S0031-0808.16.03212-2. Epub 2016 Jun 16.
9
Polymorphisms in three obesity-related genes (LEP, LEPR, and PON1) and breast cancer risk: a meta-analysis.三个肥胖相关基因（LEP、LEPR和PON1）的多态性与乳腺癌风险：一项荟萃分析。
Tumour Biol. 2011 Dec;32(6):1233-40. doi: 10.1007/s13277-011-0227-9. Epub 2011 Sep 2.
10
Association of paraoxonase 1 (PON1) L55M and PON1 Q192R gene polymorphisms and risk of psoriasis.载脂蛋白 1（PON1）L55M 和 PON1 Q192R 基因多态性与银屑病风险的关联。
G Ital Dermatol Venereol. 2019 Jun;154(3):321-326. doi: 10.23736/S0392-0488.17.05514-6. Epub 2017 Apr 11.

引用本文的文献

1
Insights into the molecular and genetic role of obesity in breast cancer pathogenesis.肥胖在乳腺癌发病机制中的分子和遗传作用的见解。
Cancer Biol Ther. 2025 Dec;26(1):2501345. doi: 10.1080/15384047.2025.2501345. Epub 2025 May 12.
2
Link Between Metabolic Syndrome, Blood Lipid Markers, Dietary Lipids, and Survival in Women with Early-Stage Breast Cancer.代谢综合征、血脂标志物、膳食脂质与早期乳腺癌女性生存的关系。
Nutrients. 2024 Oct 22;16(21):3579. doi: 10.3390/nu16213579.
3
Paraoxonase Role in Human Neurodegenerative Diseases.对氧磷酶在人类神经退行性疾病中的作用。
Antioxidants (Basel). 2020 Dec 24;10(1):11. doi: 10.3390/antiox10010011.

本文引用的文献

1
The Association between PON1 (Q192R and L55M) Gene Polymorphisms and Risk of Cancer: A Meta-Analysis Based on 43 Studies.PON1（Q192R 和 L55M）基因多态性与癌症风险的关联：基于 43 项研究的荟萃分析。
Biomed Res Int. 2019 Jul 28;2019:5897505. doi: 10.1155/2019/5897505. eCollection 2019.
2
Association analysis of the common varieties of IL17A and IL17F genes with the risk of knee osteoarthritis.白细胞介素17A（IL17A）和白细胞介素17F（IL17F）基因常见变体与膝关节骨关节炎风险的关联分析。
J Cell Biochem. 2019 Oct;120(10):18020-18030. doi: 10.1002/jcb.29105. Epub 2019 May 29.
3
Protective effect of oestrogen receptor α-PvuII transition against idiopathic male infertility: a case-control study and meta-analysis.雌激素受体 α-PvuII 转换对特发性男性不育的保护作用：病例对照研究和荟萃分析。
Reprod Biomed Online. 2019 Apr;38(4):588-598. doi: 10.1016/j.rbmo.2019.01.008. Epub 2019 Jan 23.
4
Arg399Gln substitution in XRCC1 as a prognostic and predictive biomarker for prostate cancer: Evidence from 8662 subjects and a structural analysis.XRCC1 基因 Arg399Gln 取代与前列腺癌的预后和预测生物标志物：来自 8662 例患者的证据和结构分析。
J Gene Med. 2018 Oct;20(10-11):e3053. doi: 10.1002/jgm.3053. Epub 2018 Sep 26.
5
Evaluating intrinsic and non-intrinsic cancer risk factors.评估内在和非内在癌症风险因素。
Nat Commun. 2018 Aug 28;9(1):3490. doi: 10.1038/s41467-018-05467-z.
6
Lipoprotein lipase gene polymorphisms as risk factors for stroke: a computational and meta-analysis.脂蛋白脂肪酶基因多态性作为中风的危险因素：一项计算与荟萃分析。
Iran J Basic Med Sci. 2018 Jul;21(7):701-708. doi: 10.22038/IJBMS.2018.29009.7001.
7
Role of Steroid Therapy after Ischemic Stroke by n-Methyl-d-Aspartate Receptor Gene Regulation.N-甲基-D-天冬氨酸受体基因调控在缺血性中风后类固醇治疗中的作用
J Stroke Cerebrovasc Dis. 2018 Nov;27(11):3066-3075. doi: 10.1016/j.jstrokecerebrovasdis.2018.06.041. Epub 2018 Jul 30.
8
IL-1RA VNTR and IL-1α 4845G>T polymorphisms and risk of idiopathic male infertility in Iranian men: A case-control study and an in silico analysis.白细胞介素-1受体拮抗剂可变数目串联重复序列及白细胞介素-1α 4845G>T多态性与伊朗男性特发性男性不育症风险：一项病例对照研究及计算机模拟分析
Andrologia. 2018 Nov;50(9):e13081. doi: 10.1111/and.13081. Epub 2018 Jul 3.
9
Oxidative stress in female cancers.女性癌症中的氧化应激
Oncotarget. 2018 May 4;9(34):23824-23842. doi: 10.18632/oncotarget.25323.
10
Association of C3953T transition in interleukin 1β gene with idiopathic male infertility in an Iranian population.白细胞介素1β基因C3953T转换与伊朗人群特发性男性不育的关联
Hum Fertil (Camb). 2019 Jun;22(2):111-117. doi: 10.1080/14647273.2017.1384857. Epub 2017 Oct 3.

对氧磷酶1-L55M基因变异与乳腺癌风险的关联：一项病例对照试验。

Association of PON1-L55M Genetic Variation and Breast Cancer Risk: A Case-Control Trial.

作者信息

Farmohammadi Amir, Momeni Ali, Bahmani Banafshe, Ghorbani Hossein, Ramzanpour Ramin

机构信息

Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.

School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Asian Pac J Cancer Prev. 2020 Jan 1;21(1):255-258. doi: 10.31557/APJCP.2020.21.1.255.

DOI:10.31557/APJCP.2020.21.1.255
PMID:31983193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7294023/
Abstract

BACKGROUND

Paraoxonase 1 (PON1), a multifactorial antioxidant enzyme, has a defensive role against oxidative stress, which is believed to contribute to cancer development. This study aimed to investigate the association of PON1-L55M functional polymorphism with breast cancer risk.

MATERIAL AND METHODS

In the experimental study, blood samples were collected from 150 healthy women controls and 150 breast cancer subjects. The L55M genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

Our analysis showed that the genotypes distribution is in Hardy-Weinberg equilibrium for both case and control groups. Our data revealed that there are significant associations between PON1-L55M polymorphism and breast cancer risk in homozygote (OR= 2.13, 95%CI= 1.14-4.00, p= 0.018), dominant (OR= 1.72, 95%CI= 1.07-2.76, p= 0.024), and allelic (OR= 1.55, 95%CI= 1.12-2.15, p= 0.008) models.

CONCLUSIONS

Our results suggest that the PON1-L55M genetic variation could be a genetic risk factor for breast cancer risk and it could be considered as a molecular biomarker for screening of susceptible women.
.

摘要

背景

对氧磷酶1（PON1）是一种多因素抗氧化酶，对氧化应激具有防御作用，而氧化应激被认为与癌症的发生发展有关。本研究旨在探讨PON1-L55M功能多态性与乳腺癌风险之间的关联。

材料与方法

在实验研究中，采集了150名健康女性对照者和150名乳腺癌患者的血样。通过聚合酶链反应-限制性片段长度多态性进行L55M基因分型。

结果

我们的分析表明，病例组和对照组的基因型分布均处于哈迪-温伯格平衡。我们的数据显示，在纯合子（OR = 2.13，95%CI = 1.14 - 4.00，p = 0.018）、显性（OR = 1.72，95%CI = 1.07 - 2.76，p = 0.024）和等位基因（OR = 1.55，95%CI = 1.12 - 2.15，p = 0.008）模型中，PON1-L55M多态性与乳腺癌风险之间存在显著关联。

结论

我们的结果表明，PON1-L55M基因变异可能是乳腺癌风险的一个遗传危险因素，可被视为筛查易感女性的分子生物标志物。