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Pro-oxidant activity of Cu,Zn-superoxide dismutase.铜锌超氧化物歧化酶的促氧化活性
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Regulation of the synthesis of superoxide dismutases in rat lungs during oxidant and hyperthermic stresses.氧化应激和热应激期间大鼠肺中超氧化物歧化酶合成的调节
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Cloning, production and characterisation of a recombinant Cu/Zn superoxide dismutase from Taenia solium.猪带绦虫重组铜/锌超氧化物歧化酶的克隆、生产及特性分析
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Pro-Oxidant Activity of an ALS-Linked SOD1 Mutant in Zn-Deficient Form.锌缺乏形式下与 ALS 相关的 SOD1 突变体的促氧化剂活性。
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5
The amino-acid sequence of rabbit Cu-Zn superoxide dismutase.
Biol Chem Hoppe Seyler. 1988 Aug;369(8):715-25. doi: 10.1515/bchm3.1988.369.2.715.
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The structural analysis of the pro-oxidant copper-binding site of denatured apo-H43R SOD1 and the elucidation of the origin of the acquisition of the pro-oxidant activity.变性载脂蛋白-H43R超氧化物歧化酶1促氧化剂铜结合位点的结构分析及促氧化剂活性获得起源的阐明。
Phys Chem Chem Phys. 2016 Feb 14;18(6):4468-75. doi: 10.1039/c5cp07729j.
7
Change of zinc, copper, and metallothionein concentrations and the copper-zinc superoxide dismutase activity in patients with pancreatitis.胰腺炎患者锌、铜、金属硫蛋白浓度及铜锌超氧化物歧化酶活性的变化
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Mutant Cu,Zn superoxide dismutase in motor neuron disease.运动神经元病中的突变型铜锌超氧化物歧化酶
Age (Omaha). 1998 Apr;21(2):85-9. doi: 10.1007/s11357-998-0012-x.
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Effect of aging on pulmonary superoxide dismutase.衰老对肺超氧化物歧化酶的影响。
Mech Ageing Dev. 1990 Mar 1;52(1):11-26. doi: 10.1016/0047-6374(90)90141-2.
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Copper-dependent metabolism of Cu,Zn-superoxide dismutase in human K562 cells. Lack of specific transcriptional activation and accumulation of a partially inactivated enzyme.人K562细胞中铜锌超氧化物歧化酶的铜依赖性代谢。缺乏特异性转录激活及部分失活酶的积累。
Biochem J. 1994 Sep 15;302 ( Pt 3)(Pt 3):687-94. doi: 10.1042/bj3020687.

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Hydrogen Peroxide and Amyotrophic Lateral Sclerosis: From Biochemistry to Pathophysiology.过氧化氢与肌萎缩侧索硬化症:从生物化学到病理生理学
Antioxidants (Basel). 2021 Dec 27;11(1):52. doi: 10.3390/antiox11010052.
2
Thiol oxidase ability of copper ion is specifically retained upon chelation by aldose reductase.铜离子的硫醇氧化酶能力在被醛糖还原酶螯合后被特异性保留。
J Biol Inorg Chem. 2017 Jun;22(4):559-565. doi: 10.1007/s00775-017-1447-2. Epub 2017 Feb 21.

本文引用的文献

1
Oxidative stress mediates impairment of muscle function in transgenic mice with elevated level of wild-type Cu/Zn superoxide dismutase.氧化应激介导野生型铜锌超氧化物歧化酶水平升高的转基因小鼠肌肉功能受损。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3883-7. doi: 10.1073/pnas.94.8.3883.
2
A familial amyotrophic lateral sclerosis-associated A4V Cu, Zn-superoxide dismutase mutant has a lower Km for hydrogen peroxide. Correlation between clinical severity and the Km value.一种与家族性肌萎缩侧索硬化症相关的A4V铜锌超氧化物歧化酶突变体对过氧化氢的米氏常数较低。临床严重程度与米氏常数之间的相关性。
J Biol Chem. 1997 Apr 4;272(14):8861-3. doi: 10.1074/jbc.272.14.8861.
3
Prognosis in familial amyotrophic lateral sclerosis: progression and survival in patients with glu100gly and ala4val mutations in Cu,Zn superoxide dismutase.
Neurology. 1997 Jan;48(1):55-7. doi: 10.1212/wnl.48.1.55.
4
A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.一种与肌萎缩侧索硬化相关的铜锌超氧化物歧化酶突变体的功能获得:由于过氧化氢的米氏常数降低导致自由基形成增加。
Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):5709-14. doi: 10.1073/pnas.93.12.5709.
5
Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis.家族性肌萎缩侧索硬化中超氧化物歧化酶的反应性改变。
Science. 1996 Jan 26;271(5248):515-8. doi: 10.1126/science.271.5248.515.
6
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.铜锌超氧化物歧化酶基因突变与家族性肌萎缩侧索硬化症相关。
Nature. 1993 Mar 4;362(6415):59-62. doi: 10.1038/362059a0.
7
Enzyme function of copper, zinc superoxide dismutase as a free radical generator.铜锌超氧化物歧化酶作为自由基发生器的酶功能。
J Biol Chem. 1993 Feb 25;268(6):4099-105.
8
Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.肌萎缩侧索硬化症与铜锌超氧化物歧化酶的结构缺陷
Science. 1993 Aug 20;261(5124):1047-51. doi: 10.1126/science.8351519.
9
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.表达人类铜锌超氧化物歧化酶突变的小鼠中的运动神经元变性。
Science. 1994 Jun 17;264(5166):1772-5. doi: 10.1126/science.8209258.
10
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity.与家族性肌萎缩侧索硬化症相关的突变超氧化物歧化酶1具有显著活性。
Proc Natl Acad Sci U S A. 1994 Aug 16;91(17):8292-6. doi: 10.1073/pnas.91.17.8292.

Pro-oxidant activity of Cu,Zn-superoxide dismutase.

作者信息

Yim M B, Yim H S, Boon Chock P, Stadtman E R

出版信息

Age (Omaha). 1998 Apr;21(2):91-3. doi: 10.1007/s11357-998-0013-9.

DOI:10.1007/s11357-998-0013-9
PMID:23604358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3455720/
Abstract
摘要