衰老和氧化应激对精神运动及认知行为的影响。
The effects of aging and oxidative stress on psychomotor and cognitive behavior.
作者信息
Shukitt-Hale B
出版信息
Age (Omaha). 1999 Jan;22(1):9-17. doi: 10.1007/s11357-999-0002-7.
Abstract
Decrements in motor and cognitive function occur in aging, possibly due to oxidative stress-induced damage to the brain. Declines in antioxidant defense mechanisms have been postulated as a causative factor in these age-related decrements, however a clear link between oxidative stress (OS) and behavioral changes in aging has yet to be established. This review shows that age-validated psychomotor and cognitive tests are sensitive to behavioral deficits under different models of OS, including: 1) decreasing OS protection by depleting glutathione and then increasing the OS with dopamine; 2) 100% oxygen exposure; and 3) radiation. Furthermore, interventions that reduce OS result in concurrent improvements in age-associated behavioral deficits. Therefore, age-related changes in behavior may result from an inability to cope with OS that occurs throughout the life-span.
摘要
运动和认知功能的衰退在衰老过程中会出现，这可能是由于氧化应激对大脑造成的损伤。抗氧化防御机制的下降被认为是这些与年龄相关衰退的一个致病因素，然而，氧化应激（OS）与衰老行为变化之间的明确联系尚未确立。这篇综述表明，经过年龄验证的心理运动和认知测试对不同氧化应激模型下的行为缺陷很敏感，这些模型包括：1）通过消耗谷胱甘肽降低氧化应激保护，然后用多巴胺增加氧化应激；2）暴露于100%氧气中；3）辐射。此外，减少氧化应激的干预措施会同时改善与年龄相关的行为缺陷。因此，与年龄相关的行为变化可能是由于无法应对贯穿整个生命周期的氧化应激所致。
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本文引用的文献
1
Psychomotor and spatial memory performance in aging male Fischer 344 rats.
Exp Gerontol. 1998 Sep;33(6):615-24. doi: 10.1016/s0531-5565(98)00024-2.
2
Spatial learning and memory deficits induced by dopamine administration with decreased glutathione.多巴胺给药导致谷胱甘肽减少所引起的空间学习和记忆缺陷。
Free Radic Biol Med. 1998 May;24(7-8):1149-58. doi: 10.1016/s0891-5849(97)00399-7.
3
Psychomotor effects of dopamine infusion under decreased glutathione conditions.谷胱甘肽水平降低时多巴胺输注的精神运动效应。
Free Radic Biol Med. 1997;23(3):412-8. doi: 10.1016/s0891-5849(97)00094-4.
4
Strategies used by hippocampal- and caudate-putamen-lesioned rats in a learning task.海马体和尾状核-壳核损伤大鼠在学习任务中使用的策略。
Neurobiol Learn Mem. 1997 Jul;68(1):32-41. doi: 10.1006/nlme.1996.3761.
5
Dissociation of hippocampal and striatal contributions to spatial navigation in the water maze.海马体和纹状体对水迷宫中空间导航贡献的分离
Neurobiol Learn Mem. 1996 Nov;66(3):305-23. doi: 10.1006/nlme.1996.0072.
6
Antioxidant treatment with phenyl-alpha-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats.用苯基-α-叔丁基硝酮（PBN）进行抗氧化治疗可改善老龄大鼠的认知能力并延长其生存期。
Neurosci Lett. 1996 Mar 1;205(3):181-4. doi: 10.1016/0304-3940(96)12417-4.
7
Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.氧化在纹状体内注射多巴胺的神经毒性作用中的作用。
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1956-61. doi: 10.1073/pnas.93.5.1956.
8
Chronic antioxidant treatment improves the cognitive performance of aged rats.
Brain Res. 1995 Sep 25;693(1-2):88-94. doi: 10.1016/0006-8993(95)00707-w.
9
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.小鼠中与年龄相关的认知功能和运动技能丧失与大脑中的氧化蛋白质损伤有关。
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4765-9. doi: 10.1073/pnas.93.10.4765.
10
Decreases in protective enzymes correlates with increased oxidative damage in the aging mouse brain.衰老小鼠大脑中，保护性酶的减少与氧化损伤的增加相关。
Mech Ageing Dev. 1995 Jul 14;81(2-3):73-82. doi: 10.1016/0047-6374(95)01586-o.
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