矢车菊素和浆果摄入量与阿尔茨海默病神经病理学的关系：一项基于社区的研究。
Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study.
机构信息
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
出版信息
J Alzheimers Dis. 2022;88(2):653-661. doi: 10.3233/JAD-215600.
BACKGROUND
An anthocyanidin, pelargonidin, primarily found in berries, has antioxidant and anti-inflammatory properties, and is associated with better cognition and reduced Alzheimer's dementia risk.
OBJECTIVE
This study investigated if pelargonidin or berry intake is associated with Alzheimer's disease (AD) neuropathology in human brains.
METHODS
The study was conducted among 575 deceased participants (age at death = 91.3±6.1 years; 70% females) of the Rush Memory and Aging Project, with dietary data (assessed using a food frequency questionnaire) and neuropathological evaluations. Calorie-adjusted pelargonidin intake was modeled in quartiles and berry intake as continuous (servings/week). Mean amyloid-beta load and phosphorylated tau neuronal neurofibrillary tangle density across multiple cortical regions were assessed using immunohistochemistry. Global AD pathology burden, a quantitative summary score of neurofibrillary tangles, and diffuse and neuritic plaques using Bielschowsky silver stains in multiple brain regions, was also assessed.
RESULTS
In a linear regression model adjusted for age at death, sex, education, APOE ɛ4 status, vitamin E, and vitamin C, participants in the highest quartile of pelargonidin intake when compared to those in the lowest quartile, had less amyloid-β load (β (SE) = -0.293 (0.14), p = 0.038), and fewer phosphorylated tau tangles (β (SE) = -0.310, p = 0.051). Among APOE ɛ4 non-carriers, higher strawberry (β (SE) = -0.227 (0.11), p = 0.037) and pelargonidin (Q4 versus Q1: β (SE) = -0.401 (0.16), p = 0.011; p trend = 0.010) intake was associated with less phosphorylated tau tangles, no association was observed in APOE ɛ4 carriers. Berry intake was not associated with AD pathology. However, excluding participants with dementia or mild cognitive impairment at baseline, strawberry (p = 0.004) and pelargonidin (ptrend = 0.007) intake were associated with fewer phosphorylated tau tangles.
CONCLUSION
Higher intake of pelargonidin, a bioactive present in strawberries, is associated with less AD neuropathology, primarily phosphorylated tau tangles.
背景
矢车菊素，主要存在于浆果中的一种花色苷，具有抗氧化和抗炎特性，与更好的认知能力和降低阿尔茨海默病痴呆风险有关。
目的
本研究旨在探讨矢车菊素或浆果的摄入是否与人类大脑中的阿尔茨海默病（AD）神经病理学有关。
方法
该研究在 Rush 记忆与衰老项目的 575 名已故参与者（死亡时年龄为 91.3±6.1 岁；70%为女性）中进行，参与者的饮食数据（通过食物频率问卷评估）和神经病理学评估。采用四分位数法对校正热量后的矢车菊素摄入量进行建模，并用每周摄入量（份）来表示浆果摄入量。使用免疫组织化学方法评估多个皮质区域的平均淀粉样β负荷和磷酸化tau 神经元神经原纤维缠结密度。还使用 Bielschowsky 银染评估多个脑区的 AD 病理总负担、神经原纤维缠结的定量综合评分、弥漫性和神经突斑块。
结果
在调整死亡时年龄、性别、教育程度、APOE ε4 状态、维生素 E 和维生素 C 的线性回归模型中，与最低四分位数相比，摄入矢车菊素最高四分位数的参与者的淀粉样β负荷较低（β（SE）=-0.293（0.14），p=0.038），磷酸化 tau 缠结也较少（β（SE）=-0.310，p=0.051）。在 APOE ε4 非携带者中，较高的草莓（β（SE）=-0.227（0.11），p=0.037）和矢车菊素（Q4 与 Q1：β（SE）=-0.401（0.16），p=0.011；p 趋势=0.010）摄入量与磷酸化 tau 缠结较少有关，而在 APOE ε4 携带者中则没有观察到这种关联。浆果摄入量与 AD 病理无关。然而，排除基线时患有痴呆或轻度认知障碍的参与者后，草莓（p=0.004）和矢车菊素（ptrend=0.007）的摄入量与较少的磷酸化 tau 缠结有关。
结论
较高的矢车菊素（一种存在于草莓中的生物活性物质）摄入量与 AD 神经病理学有关，主要是磷酸化 tau 缠结。
Zotero 插件