Inoue S, Yokoyama S, Nakayama I, Noguchi S
First Department of Pathology, Medical College of Oita, Japan.
Acta Pathol Jpn. 1990 Mar;40(3):187-92. doi: 10.1111/j.1440-1827.1990.tb03321.x.
Parafollicular cells (C-cells) in benign and malignant thyroid lesions were studied immunohistochemically with a polyclonal anti-calcitonin (CT) antibody. The C-cells were seen most frequently in the middle third of the lateral lobes in the thyroid gland of normal individuals and patients with Graves' disease and chronic thyroiditis, although in the latter the number of such cells was significantly decreased (p less than 0.05). In adenomatous goiter, C-cells were present in nodular lesions from an early stage of nodule development (frequency about 19%), whereas in the later stage these cells were rarely observed inside type 1 nodules, which were generally characterized by an admixture of follicles with considerably different sizes. However, C-cells were not observed inside type 2 nodules, which were composed of similar-sized follicles, or in the parenchyma of 56 cases of benign and malignant thyroid tumors. These findings suggest that since C-cells are present in nodular lesions, the histogenesis of adenomatous goiter is quite different from that of follicular adenoma; thyroid neoplasms generally contain no C-cells in the parenchyma.
采用多克隆抗降钙素（CT）抗体，对良性和恶性甲状腺病变中的滤泡旁细胞（C细胞）进行免疫组织化学研究。在正常个体、格雷夫斯病患者和慢性甲状腺炎患者的甲状腺侧叶中三分之一处，最常观察到C细胞，不过在慢性甲状腺炎患者中，此类细胞的数量显著减少（p<0.05）。在腺瘤性甲状腺肿中，从结节发育早期开始，C细胞就存在于结节性病变中（频率约为19%），而在后期，在1型结节内部很少观察到这些细胞，1型结节通常以大小差异较大的滤泡混合为特征。然而，在由大小相似的滤泡组成的2型结节内部，或在56例良性和恶性甲状腺肿瘤的实质中，均未观察到C细胞。这些发现表明，由于C细胞存在于结节性病变中，腺瘤性甲状腺肿的组织发生与滤泡性腺瘤截然不同；甲状腺肿瘤的实质中通常不含C细胞。
