Li Guo, Gao Jin, Liu Zhi-Gang, Tao Ya-Lan, Xu Bing-Qing, Tu Zi-Wei, Zhang Xiu-Ping, Zeng Mu-Sheng, Xia Yun-Fei
State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University, Guangzhou, People's Republic of China; Department of Radiation Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China; Department of Radiation Oncology, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, People's Republic of China.
Head Neck. 2014 May;36(5):660-6. doi: 10.1002/hed.23357. Epub 2013 Jul 30.
The purpose of this study was to investigate the relationship between pretreatment nutritional status and prognosis of nasopharyngeal carcinoma (NPC).
Pretreatment nutritional status was evaluated by ideal body weight percentile (IBW%) and serum albumin for 512 patients with NPC who underwent radical radiotherapy. Kaplan-Meier methods, log-rank test, and a Cox model were applied for survival analysis.
Before radiotherapy, IBW% <90% was related to poorer overall survival (OS) and distant metastasis-free survival (DMFS; p = .031 and p = .012, respectively); albumin ≤43.0 g/L was related to poorer OS and DMFS (p < .001 and p = .042, respectively); both IBW% and albumin were independent prognostic factors for OS; those patients with IBW% <90% and albumin ≤43.0 g/L simultaneously had the worst OS and DMFS.
Decrease of pretreatment IBW% and albumin was related to poorer survival of NPC.
本研究旨在探讨鼻咽癌（NPC）患者治疗前营养状况与预后之间的关系。
采用理想体重百分比（IBW%）和血清白蛋白对512例行根治性放疗的NPC患者的治疗前营养状况进行评估。应用Kaplan-Meier法、对数秩检验和Cox模型进行生存分析。
放疗前，IBW%<90%与较差的总生存期（OS）和无远处转移生存期（DMFS）相关（分别为p = 0.031和p = 0.012）；白蛋白≤43.0 g/L与较差的OS和DMFS相关（分别为p<0.001和p = 0.042）；IBW%和白蛋白均为OS的独立预后因素；同时具有IBW%<90%和白蛋白≤43.0 g/L的患者OS和DMFS最差。
治疗前IBW%和白蛋白的降低与NPC患者较差的生存率相关。
