抗体功能化磁性聚合物囊泡：高分辨率 MRI 用于骨转移的体内靶向和成像。
Antibody-functionalized magnetic polymersomes: in vivo targeting and imaging of bone metastases using high resolution MRI.
机构信息
Centre de Résonance Magnétique, des Systèmes Biologiques, UMR 5536, Université Bordeaux Segalen, CNRS, France.
出版信息
Adv Healthc Mater. 2013 Nov;2(11):1420-4. doi: 10.1002/adhm.201300061. Epub 2013 Apr 19.
PMID:23606565
Abstract
Multifunctional polymersomes loaded with maghemite nanoparticles and grafted with an antibody, directed against human endothelial receptor 2, are developed as novel MRI contrast agents for bone metastasis imaging. Upon administration in mice bearing bone tumor grown from human breast cancer cells, MR images show targeting and enhanced retention of antibody-labeled polymersomes at the tumor site.
摘要
多功能聚合物囊泡负载磁赤铁矿纳米粒子，并接枝针对人内皮受体 2 的抗体，被开发为用于骨转移成像的新型 MRI 对比剂。在荷有人乳腺癌细胞来源的骨肿瘤的小鼠中给药后，磁共振成像显示抗体标记的聚合物囊泡在肿瘤部位的靶向性和增强保留。
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