Guo Yunqi, Wang Zhiqiang, Shi Xiangyang, Shen Mingwu
Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology Donghua University Shanghai P. R. China.
Exploration (Beijing). 2022 Jan 25;2(1):20210171. doi: 10.1002/EXP.20210171. eCollection 2022 Feb.
For efficient cancer theranostics, surface modification of nanomaterials plays an important role in improving targeting ability and reducing the non-specific interactions with normal tissues. Recently, the biomimetic technology represented by coating of cancer cell membranes (CCMs) has been regarded as a promising method to strengthen the biocompatibility and targeting specificity of nanomaterials. Furthermore, the engineered CCMs (ECCMs) integrated with the natural biological properties of CCMs and specific functions from other cells or proteins have offered more possibilities in the field of cancer theranostics. Herein, the recent progresses in the design and preparation of ECCMs are summarized, and the applications of ECCMs in targeting delivery, activation of immunity, and detection of circulating tumor cells are reviewed. Finally, the current challenges and future perspectives with regard to the development of ECCMs are briefly discussed.
对于高效的癌症诊疗，纳米材料的表面修饰在提高靶向能力和减少与正常组织的非特异性相互作用方面起着重要作用。近年来，以癌细胞膜（CCM）包覆为代表的仿生技术被认为是增强纳米材料生物相容性和靶向特异性的一种有前景的方法。此外，将CCM的天然生物学特性与其他细胞或蛋白质的特定功能相结合的工程化癌细胞膜（ECCM）在癌症诊疗领域提供了更多可能性。在此，总结了ECCM设计与制备的最新进展，并综述了ECCM在靶向递送、免疫激活和循环肿瘤细胞检测中的应用。最后，简要讨论了ECCM发展目前面临的挑战和未来前景。
