Flenley D C, Fairweather L J, Cooke N J, Kirby B J
Br Med J. 1975 Mar 15;1(5958):602-4. doi: 10.1136/bmj.1.5958.602.
Direct measurements of the factors determining blood oxygen transport in 10 patients with chronic hypoxic respiratory failure led to the conclusion that wide differences in the position of their oxygen binding curves, due to spontaneous differences in red-cell 2, 3-diphosphoglycerate, had little effect on oxygen delivery to the tissues, as assessed by the mixed venous oxygen tension when they were breathing air. This result arises from the shape of the oxygen binding curve. A drug which could shift the curve to the right would help tissue oxygenation in cardiogenic and other forms of shock, when a low cardiac output can not be improved though arterial blood can be well oxygenated.
对10例慢性低氧性呼吸衰竭患者决定血氧运输的因素进行直接测量后得出结论：由于红细胞2,3 -二磷酸甘油酸自发存在差异，其氧结合曲线位置存在很大差异，但对呼吸空气时通过混合静脉血氧分压评估的组织氧输送影响很小。这一结果源于氧结合曲线的形状。一种能使曲线右移的药物，在心源性休克和其他形式的休克中，当尽管动脉血能充分氧合但低心输出量无法改善时，将有助于组织氧合。
