Small S A, MacDonald C, Farrell A P
Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Am J Physiol. 1990 Jun;258(6 Pt 2):R1402-10. doi: 10.1152/ajpregu.1990.258.6.R1402.
Vascular reactivity of the large coronary artery of a lower vertebrate was investigated for the first time in this study. The responses of vascular rings to various pharmacological agents were measured using isometric force transducers. Coronary arteries from rainbow trout, Oncorhynchus mykiss, contracted with acetylcholine and predominantly relaxed with isoproterenol, epinephrine, norepinephrine, and serotonin. Atenolol blocked the adrenergic relaxation, suggesting a predominance of beta 1-adrenoceptors. Nitroglycerin and sodium nitroprusside relaxed vascular rings. Responses to histamine and bradykinin were absent in this tissue. Adenosine, ADP, and ATP caused contractions that could be blocked by theophylline. The difference in vascular reactivity between that typically found in mammalian coronary arteries and that reported here for rainbow trout are discussed.
本研究首次对一种低等脊椎动物的大冠状动脉的血管反应性进行了研究。使用等长力传感器测量血管环对各种药理剂的反应。虹鳟（Oncorhynchus mykiss）的冠状动脉与乙酰胆碱发生收缩反应，而与异丙肾上腺素、肾上腺素、去甲肾上腺素和5-羟色胺主要发生舒张反应。阿替洛尔阻断了肾上腺素能舒张反应，提示β1-肾上腺素能受体占主导地位。硝酸甘油和硝普钠使血管环舒张。该组织对组胺和缓激肽无反应。腺苷、二磷酸腺苷和三磷酸腺苷引起的收缩反应可被茶碱阻断。文中讨论了哺乳动物冠状动脉中典型的血管反应性与本文报道的虹鳟血管反应性之间的差异。
