[硝苯地平和乌拉地尔对颅内占位性病变时脑循环自动调节的影响]

[Effect of nifedipine and urapidil on autoregulation of cerebral circulation in the presence of an intracranial space occupying lesion].

作者信息

Wüsten R, Hemelrijck J, Mattheussen M, Lauwers T, Anger C, Van Aken H

机构信息

Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Westfälischen Wilhelms-Universität Münster.

出版信息

Anasth Intensivther Notfallmed. 1990 Apr;25(2):140-5.

PMID:2360708

Abstract

We investigated in dogs with an intracranial space occupying lesion the effects of the antihypertentive agents nifedipine and urapidile on intracranial pressure (ICP) and intracerebral autoregulation. During the application of nifedipine the ICP rose significantly whereas urapidile had no influence on the ICP. By continuous angiotensin infusion the mean arterial pressure was raised by 50% by which a simultaneous increase of the ICP could be seen in the nifedipine group, whereas the urapidile group remained unaffected.

摘要

我们在患有颅内占位性病变的犬类中研究了降压药物硝苯地平和乌拉地尔对颅内压（ICP）和脑内自动调节的影响。在应用硝苯地平期间，颅内压显著升高，而乌拉地尔对颅内压没有影响。通过持续输注血管紧张素，平均动脉压升高了50%，在此情况下硝苯地平组颅内压同时升高，而乌拉地尔组则未受影响。