Fernández F, González C, Gómez G, López C, Medina L, Calleja J M, Cano E
Departmento de Química Organica, Facultad de Farmacia, Universidad de Santiago, Spain.
Arch Pharm (Weinheim). 1990 Apr;323(4):239-42. doi: 10.1002/ardp.19903230412.
The phenanthrylethanols 2a-d were obtained by reduction of the acetyl derivatives 1a-d and converted, through the phenanthrylethyl halides 3a-d and 4b, into the nitriles 5a-d, whose acid hydrolysis afforded the acids of the title, 6a-d. The antiinflammatory activity of these acids was measured on the carrageenin-induced edema and found as 1/3 (6a), 1/43 (6b), 1/5 (6c), and 1/7 (6d) of that of fenbufen.
通过还原乙酰衍生物1a - d得到菲基乙醇2a - d，并通过菲基乙基卤化物3a - d和4b将其转化为腈5a - d，腈5a - d经酸性水解得到标题中的酸6a - d。在角叉菜胶诱导的水肿实验中测定了这些酸的抗炎活性，发现其活性分别为芬布芬的1/3（6a）、1/43（6b）、1/5（6c）和1/7（6d）。
