非甾体抗炎药。第20(3)部分：旋光性噻吩基-联苯基-羟基丙酸
Nonsteroidal antiinflammatory agents. Part 20(3): Optically active thienyl-biphenylyl-hydroxypropionic acids.
作者信息
Varoli L, Burnelli S, Guarnieri A, Scapini G, Andrisano V, Fantuz M
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Bologna, Italia.
出版信息
Pharmazie. 1990 Jul;45(7):488-90.
PMID:2236191
Abstract
The optically active diastereometric erythro- and threo-3-thienyl-analogues 6a-d of 3-aryl-2-biphenylyl-3-hydroxy-propionic acids have been prepared. Some stereoisomers of 3-(3-thienyl)derivative 6b showed inhibition around 40% in the carrageenan-induced rat paw edema test.
摘要
已制备出3-芳基-2-联苯基-3-羟基丙酸的旋光非对映体赤型和苏型-3-噻吩基类似物6a-d。3-(3-噻吩基)衍生物6b的一些立体异构体在角叉菜胶诱导的大鼠足爪水肿试验中显示出约40%的抑制率。
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