因急性中耳炎住院是疾病严重程度的有用标志物。

Hospitalization for acute otitis media as a useful marker for disease severity.

机构信息

From the *Department of Health Management and Health Economics, University of Oslo; †Research, Innovation and Education, Oslo University Hospital, Ullevål; ‡Department of Otolaryngology, Ostfold Hospital Trust; and §Centre of Clinical Research, Unit of Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.

出版信息

Pediatr Infect Dis J. 2013 Sep;32(9):946-9. doi: 10.1097/INF.0b013e318297c436.

DOI:10.1097/INF.0b013e318297c436

PMID:23609040

Abstract

BACKGROUND

An increase in severe complications to otitis media is a potential threat to antibiotic restrictions and is difficult to measure due to its low-prevalent nature. Easily accessible indicators sensitive to illness change are needed to benchmark the judicious use of antibiotics.

OBJECTIVE

To investigate whether there has been a constant increase of hospital admissions for acute otitis media after the year 2000.

METHODS

Registry-based study with complete data on hospitalization for acute otitis media and acute mastoiditis in Norway during 1999 to 2006.

RESULTS

Mean incidence rate for acute otitis media hospitalization was 22.4 per 10,000 children and peak incidence in the second year of life 52.2 per 10,000 children. Corresponding mean incidence rate and peak incidence for acute mastoiditis were 1.5 and 3.5 per 10,000 children in the second year of life, respectively. There was a gradient increase of the incidence rates of acute otitis media hospitalization from the year 2000 to 2006 considering the Poisson regression model with a significant test of linear trend.

CONCLUSIONS

Hospital admission for acute otitis media is prevalent enough to be a useful marker for otitis media severity and its distribution proportionate to that of acute mastoiditis.

摘要

背景

中耳炎严重并发症的增加对抗生素限制构成了潜在威胁，由于其低流行率，因此难以衡量。需要易于获得的、对疾病变化敏感的指标来衡量抗生素的合理使用。

目的

调查 2000 年后，急性中耳炎住院人数是否持续增加。

方法

基于登记的研究，对挪威 1999 年至 2006 年期间急性中耳炎和急性乳突炎住院的完整数据进行了研究。

结果

急性中耳炎住院的平均发病率为每 10000 名儿童 22.4 例，发病高峰期为生命的第二年，为每 10000 名儿童 52.2 例。相应的急性乳突炎的平均发病率和发病高峰期分别为生命第二年每 10000 名儿童 1.5 和 3.5 例。考虑到泊松回归模型，急性中耳炎住院的发病率从 2000 年到 2006 年呈梯度上升，线性趋势检验具有统计学意义。