阿米巴病患者的免疫反应：IgG亚类评估

Immune response in patients with amoebiasis: evaluation of IgG-subclasses.

作者信息

Kollaritsch H, Stock C, Scheiner O, Stemberger H, Wiedermann G

机构信息

Institut für Spezifische Prophylaxe und Tropenmedizin der Universität, Wien, Osterreich.

出版信息

Zentralbl Bakteriol. 1990 Apr;272(4):535-9. doi: 10.1016/s0934-8840(11)80055-1.

DOI:10.1016/s0934-8840(11)80055-1

PMID:2360971

Abstract

In order to evaluate the immune response with respect to IgG-subclasses (IgG1-IgG4) in patients with extraintestinal amoebiasis, an ELISA technique was established. It was the aim of this pilot study to quantify the IgG subclass response and to compare the resulting pattern with other systemic protozoal infections. Our results give evidence that IgG4 contributes to more than one third of the total immune response, followed by IgG2, IgG3 and IgG1. Regarding the IgG4 response in patients with Plasmodium falciparum malaria or Chagas disease, IgG4 plays only a minor role in these systemic protozoal infections. The interpretation of a prognostic value of the high IgG4 titres in our patients is not possible at present. However, in patients with a prolonged clinical course of extraintestinal amoebiasis, extremely high IgG4 titres were observed.

摘要

为了评估肠外阿米巴病患者针对IgG亚类（IgG1 - IgG4）的免疫反应，建立了一种酶联免疫吸附测定（ELISA）技术。这项初步研究的目的是量化IgG亚类反应，并将所得模式与其他全身性原生动物感染进行比较。我们的结果表明，IgG4在总免疫反应中占比超过三分之一，其次是IgG2、IgG3和IgG1。关于恶性疟原虫疟疾或恰加斯病患者的IgG4反应，IgG4在这些全身性原生动物感染中仅起次要作用。目前尚无法解读我们患者中高IgG4滴度的预后价值。然而，在肠外阿米巴病临床病程较长的患者中，观察到了极高的IgG4滴度。