Gusein-Zade S M
Moscow State University, Lenin Hills, USSR.
J Biomol Struct Dyn. 1990 Apr;7(5):1185-97. doi: 10.1080/07391102.1990.10508555.
This is a sequel to the paper, where a model which describes ranged series of codon frequencies was proposed. The model was tested against the empirical distributions obtained for the best studied species and was on the whole found to be in fairly good agreement with the available data. The few deviations from the model's predictions were found to have a monotypic regularity. In the present paper we proceed on the assumption that the deviations are due to inhomogeneous conditions of molecular evolution within a genome. This approach makes it possible to elaborate the theory presented earlier. An improved model is derived for the ranged distribution of codon frequencies, which is then tested against the experimental data.
本文是前文的续篇，前文提出了一个描述密码子频率范围系列的模型。该模型针对最佳研究物种获得的经验分布进行了测试，总体上发现与现有数据相当吻合。发现与模型预测的少数偏差具有单一型规律。在本文中，我们基于这样的假设进行研究，即这些偏差是由于基因组内分子进化的不均匀条件所致。这种方法使得详细阐述先前提出的理论成为可能。我们推导出了一个改进的密码子频率范围分布模型，然后针对实验数据对其进行了测试。
