Rizzoli Orthopaedic Institute, Biomechanics Laboratory and II Orthopaedic Clinic, Via di Barbiano n. 1/10, Bologna 40136, Italy.
Bone Joint Res. 2013 Feb 1;2(2):18-25. doi: 10.1302/2046-3758.22.2000092. Print 2013 Feb.
Matrix-assisted autologous chondrocyte transplantation (MACT) has been developed and applied in the clinical practice in the last decade to overcome most of the disadvantages of the first generation procedures. The purpose of this systematic review is to document and analyse the available literature on the results of MACT in the treatment of chondral and osteochondral lesions of the knee.
ALL STUDIES PUBLISHED IN ENGLISH ADDRESSING MACT PROCEDURES WERE IDENTIFIED, INCLUDING THOSE THAT FULFILLED THE FOLLOWING CRITERIA: 1) level I-IV evidence, 2) measures of functional or clinical outcome, 3) outcome related to cartilage lesions of the knee cartilage.
The literature analysis showed a progressively increasing number of articles per year. A total of 51 articles were selected: three randomised studies, ten comparative studies, 33 case series and five case reports. Several scaffolds have been developed and studied, with good results reported at short to medium follow-up.
MACT procedures are a therapeutic option for the treatment of chondral lesions that can offer a positive outcome over time for specific patient categories, but high-level studies are lacking. Systematic long-term evaluation of these techniques and randomised controlled trials are necessary to confirm the potential of this treatment approach, especially when comparing against less ambitious traditional treatments.
基质辅助自体软骨细胞移植（MACT）在过去十年中得到了发展和应用，以克服第一代手术的大多数缺点。本系统评价的目的是记录和分析 MACT 治疗膝关节软骨和软骨下病变的现有文献，以评估其结果。
确定了所有以 MACT 程序为主题并发表在英文期刊上的研究，这些研究必须符合以下标准：1）I-IV 级证据，2）功能或临床结果的测量，3）与膝关节软骨病变相关的结果。
文献分析显示，每年的文章数量呈递增趋势。共选择了 51 篇文章：三篇随机研究、十篇对照研究、三十三例病例系列研究和五篇病例报告。已经开发和研究了几种支架，在短期到中期随访中报告了良好的结果。
MACT 程序是治疗软骨病变的一种治疗选择，对于特定的患者群体，随着时间的推移可以提供积极的结果，但缺乏高级别的研究。需要对这些技术进行系统的长期评估和随机对照试验，以确认这种治疗方法的潜力，特别是在与不那么有抱负的传统治疗方法进行比较时。
