Gibbons D O, Lant A F
Clin Pharmacol Ther. 1975 May;17(5):578-84. doi: 10.1002/cpt1975175578.
The separate effects of propantheline, atropine, and metoclopramide on ethanol absorption have been studied in man. Intravenous propantheline lowered blood ethanol levels after ingestion of a standard ethanol load. Oral propantheline, at dose levels currently recommended for therapeutic use, was without significant effect on ethanol tolerance, whereas the tolerance was reduced by oral atropine. Propantheline bromide tablets have been shown to undergo significant hydrolysis at alkaline pH in vitro. Metoclopramide, given intravenously and orally, significant elevated blood ethanol levels soon after ingestion of a standard ethanol load. It is suggested that when propantheline is selected as an anticholinergic for clinical use, there is need for greater awareness of the marked reduction in bioavailablity that results when the drug is administered at conventional therapeutic dosage by the oral as opposed to the intravenous route.
已在人体中研究了丙胺太林、阿托品和甲氧氯普胺对乙醇吸收的单独作用。静脉注射丙胺太林可降低摄入标准乙醇负荷后的血液乙醇水平。目前推荐用于治疗的剂量水平的口服丙胺太林对乙醇耐受性无显著影响，而口服阿托品会降低耐受性。已证明溴丙胺太林片在体外碱性pH条件下会发生显著水解。静脉注射和口服甲氧氯普胺后，在摄入标准乙醇负荷后不久会显著提高血液乙醇水平。建议在选择丙胺太林作为临床使用的抗胆碱能药物时，需要更加意识到当通过口服而非静脉途径以常规治疗剂量给药时，药物的生物利用度会显著降低。
