关于酒精吸收与胃排空速率之间关系的观察
Observations on the relation between alcohol absorption and the rate of gastric emptying.
作者信息
Holt S
出版信息
Can Med Assoc J. 1981 Feb 1;124(3):267-77, 297.
Abstract
Alcohol (ethanol) is absorbed slowly from the stomach and rapidly from the small intestine, and the rate of its absorption depends on the rate of gastric emptying. When gastric emptying is fast, the absorption of alcohol is fast. When gastric emptying is slow the absorption of alcohol is delayed and peak blood alcohol concentrations are reduced. Alterations of the gastric emptying rate, which may have a physiologic, pharmacologic or pathologic cause, markedly influence the rate of alcohol absorption. The gastric emptying rate makes an important contribution to inter- and intraindividual variations in the rate of alcohol absorption and therefore the timing and magnitude of the acute intoxicating effect of an oral dose of alcohol.
摘要
酒精（乙醇）在胃中吸收缓慢，在小肠中吸收迅速，其吸收速率取决于胃排空速率。当胃排空快时，酒精吸收快。当胃排空慢时，酒精吸收延迟，血中酒精浓度峰值降低。胃排空速率的改变可能有生理、药理或病理原因，会显著影响酒精吸收速率。胃排空速率对个体间和个体内酒精吸收速率的差异有重要影响，因此也影响口服一定剂量酒精产生急性中毒效应的时间和程度。
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本文引用的文献
1
An evaluation of indium DTPA chelate in the measurement of gastric emptying by scintiscanning.铟 DTPA 螯合物在闪烁扫描法测定胃排空中的评价。
Gut. 1971 Aug;12(8):611-5. doi: 10.1136/gut.12.8.611.
2
The osmotic effects of some simple molecules and ions on gastric emptying.一些简单分子和离子对胃排空的渗透作用。
J Physiol. 1960 Dec;154(2):254-69. doi: 10.1113/jphysiol.1960.sp006577.
3
Estimation of the level of blood alcohol from analysis of breath.通过呼气分析估算血液酒精含量。
J Lab Clin Med. 1950 Aug;36(2):306-18.
4
The metabolism of ethyl alcohol.乙醇的代谢
Pharmacol Rev. 1952 Jun;4(2):107-35.
5
Studies of undernutrition, Wuppertal 1946-9. XXV. Radiological observations on the bones.营养不良研究，伍珀塔尔，1946 - 1949年。第二十五部分。骨骼的放射学观察。
Spec Rep Ser Med Res Counc (G B). 1951;275:289-95.
6
The pattern of emptying of the human stomach.人类胃部的排空模式。
J Physiol. 1951 Apr;113(2-3):157-68. doi: 10.1113/jphysiol.1951.sp004562.
7
Some pharmacologic effects of dioctyl sodium sulfosuccinate on the gastrointestinal tract of the rat.二辛基磺基琥珀酸钠对大鼠胃肠道的某些药理作用。
Gastroenterology. 1961 Dec;41:580-4.
8
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Surg Gynecol Obstet. 1964 Dec;119:1256-8.
9
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Acta Gastroenterol Belg. 1964 Feb;27:129-47.
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