[肾脏原发性甲状腺样滤泡癌的临床病理特征]
[Clinicopathologic characteristics of primary thyroid-like follicular carcinoma in kidney].
作者信息
Wu Huan-wen, Chen Wen-jing, You Yan, Cui Quan-cai, Liu Tong-hua
机构信息
Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
出版信息
Zhonghua Bing Li Xue Za Zhi. 2013 Jan;42(1):37-41. doi: 10.3760/cma.j.issn.0529-5807.2013.01.008.
OBJECTIVE
To explore the clinicopathological characteristics of primary thyroid-like follicular carcinoma of the kidney.
METHODS
A case of primary thyroid-like follicular carcinoma of the kidney was studied with histology and immunohistochemical staining, and its clinical and pathological findings were further analyzed with review of the literature.
RESULTS
The patient was a 26-year-old asymptomatic woman who had a kidney mass during her annual physical examination. The tumor was well-circumscribed. Pathologically, the tumor showed follicular structures with colloid-like material in the lumina. Immunohistochemically, the tumor cells showed intense staining for CK7 and vimentin and negative for thyoid transcripation factor-1, thyroglobulin, thyoid peroxidase and RCC.
CONCLUSIONS
The diagnosis of primary thyroid-like follicular carcinoma of the kidney is based on the characteristic follicular architecture with colloid-like material, and the metastasis from a thyroid follicular carcinoma must be excluded clinically and pathologically before making the final diagnosis.
目的
探讨原发性肾甲状腺样滤泡癌的临床病理特征。
方法
对1例原发性肾甲状腺样滤泡癌进行组织学及免疫组化染色研究，并复习文献进一步分析其临床及病理表现。
结果
患者为26岁无症状女性，年度体检时发现肾脏肿块。肿瘤边界清晰。病理上，肿瘤呈现滤泡结构，管腔内有胶样物质。免疫组化显示，肿瘤细胞CK7和波形蛋白呈强阳性，甲状腺转录因子-1、甲状腺球蛋白、甲状腺过氧化物酶及肾细胞癌标记物呈阴性。
结论
原发性肾甲状腺样滤泡癌的诊断基于具有胶样物质的特征性滤泡结构，在做出最终诊断前必须在临床和病理上排除甲状腺滤泡癌转移。
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