Wu William W, Chu Julia T, Nael Ali, Rezk Sherif A, Romansky Stephen G, Shane Lisa
Department of Pathology & Laboratory Medicine, University of California Irvine Medical Center, Orange, CA 92868, USA.
Department of Pathology, Long Beach Memorial Medical Center, 2801 Atlantic Avenue, Long Beach, CA 90801, USA.
Case Rep Pathol. 2014;2014:313974. doi: 10.1155/2014/313974. Epub 2014 Jul 15.
Thyroid-like follicular carcinoma of the kidney (TLFCK) is a rare histological variant of renal cell carcinoma not currently included in the World Health Organization classification of renal tumors. Only 24 previous cases of TLFCK have been reported to date. We report a case of TLFCK in a 19-year-old woman with history of pediatric acute lymphoblastic leukemia. This patient is the youngest with TLFCK to be reported to date and the first with history of lymphoblastic leukemia. The development of TLFCK in a young patient with history of lymphoblastic leukemia is interesting and suggests that genes involved in leukemogenesis may also be important for TLFCK pathogenesis. Recognition of TLFCK is important to distinguish it from other conditions that show thyroid-like features, as a misdiagnosis can result in adverse patient care.
肾甲状腺样滤泡癌（TLFCK）是肾细胞癌一种罕见的组织学变异型，目前未被纳入世界卫生组织肾肿瘤分类中。迄今为止，仅报道过24例TLFCK病例。我们报告了1例19岁患有儿童急性淋巴细胞白血病病史的女性TLFCK病例。该患者是迄今为止报道的最年轻的TLFCK患者，也是首例有淋巴细胞白血病病史的患者。一名有淋巴细胞白血病病史的年轻患者发生TLFCK很有意思，提示参与白血病发生的基因可能对TLFCK的发病机制也很重要。认识TLFCK对于将其与其他具有甲状腺样特征的疾病相鉴别很重要，因为误诊可能导致对患者不利的治疗。
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