Sohn Hyun Soon, Oh Ock Hee, Kwon Jin-Won, Lee Young Sook
College of Pharmacy, Sookmyung Women's University.
Int J Clin Pharmacol Ther. 2013 Jul;51(7):585-92. doi: 10.5414/CP201827.
This study was conducted to investigate overall systemic antibiotic consumption levels and specific patterns using standardized Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology. National Health Insurance claims data during 2008 and 2009 was used. Antibiotic prescription data was classified using the ATC system and converted into DDD. Consumption figures were presented as the number of DDD per 1,000 inhabitants per day (DID). Detailed information on indications and seasonal variations, age and institutional determinants on antibiotic consumption were also explored. Total consumption was slightly increased from 24.3 to 25.2 DID in 2009 compared to 2008. The most frequently prescribed antibiotic was amoxicillin/clavulanic acid (5.1 and 5.2 DID, in 2008 and 2009, respectively), followed by cefaclor (3.0 and 3.3 DID) and amoxicillin (3.3 and 3.2 DID). Respiratory system diseases were the main causes of antimicrobial prescription (47.3%) and acute forms of bronchitis, tonsillitis and sinusitis were the most common diseases. There were typical seasonal fluctuations with heightened winter peaks. Consumption figures under 5 years of age (41.6 and 43.3 DID) were even higher than figures in aged 65 - 80 (36.2 and 39.1 DID). Antibiotic consumption in South Korea remained high compared with other OECD countries. Efforts to increase prudent antibiotic use, especially for upper respiratory system infections and for younger children, should be made to decrease antibiotic use.
本研究旨在使用标准化的解剖治疗学分类/限定日剂量（ATC/DDD）方法，调查总体全身抗生素消费水平和具体模式。使用了2008年和2009年的国民健康保险理赔数据。抗生素处方数据采用ATC系统进行分类，并转换为DDD。消费数据以每1000居民每天的DDD数（DID）表示。还探讨了抗生素消费的适应症、季节变化、年龄和机构决定因素的详细信息。与2008年相比，2009年的总消费量从24.3 DID略有增加至25.2 DID。最常处方的抗生素是阿莫西林/克拉维酸（2008年和2009年分别为5.1和5.2 DID），其次是头孢克洛（3.0和3.3 DID）和阿莫西林（3.3和3.2 DID）。呼吸系统疾病是抗菌药物处方的主要原因（47.3%），急性支气管炎、扁桃体炎和鼻窦炎是最常见的疾病。存在典型的季节性波动，冬季高峰加剧。5岁以下儿童的消费数据（41.6和43.3 DID）甚至高于65 - 80岁人群（36.2和39.1 DID）。与其他经合组织国家相比，韩国的抗生素消费量仍然很高。应努力提高抗生素的合理使用，特别是在上呼吸道感染和年幼儿童方面，以减少抗生素的使用。
