镍催化二炔与亚甲基氮丙啶的[3 + 2]环加成反应，通过 C-C 键断裂。

Nickel-catalyzed [3 + 2] cycloaddition of diynes with methyleneaziridines via C-C bond cleavage.

机构信息

Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.

出版信息

Chem Commun (Camb). 2013 Jun 4;49(44):5073-5. doi: 10.1039/c3cc41061g. Epub 2013 Apr 24.

Abstract

A Ni-catalyzed [3 + 2] cycloaddition via C-C bond cleavage of methyleneaziridines under mild conditions was developed. This reaction gave substituted pyrroles with excellent regioselectivity and a pendant alkyne unit, which is advantageous for further derivatization.

摘要

发展了一种在温和条件下通过亚甲基氮丙啶的 C-C 键断裂的镍催化[3+2]环加成反应。该反应以优异的区域选择性和一个连有炔烃单元的取代吡咯为产物，这有利于进一步衍生化。