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一种用于远场的光学超微显微镜,可实时超越衍射极限成像。

An optical super-microscope for far-field, real-time imaging beyond the diffraction limit.

机构信息

Edward S. Rogers Sr. Department of Electrical and Computer Engineering, University of Toronto. 10 King's College Rd., Toronto, Ontario, Canada.

出版信息

Sci Rep. 2013;3:1715. doi: 10.1038/srep01715.

Abstract

Optical microscopy suffers from a fundamental resolution limitation arising from the diffractive nature of light. While current solutions to sub-diffraction optical microscopy involve combinations of near-field, non-linear and fine scanning operations, we hereby propose and demonstrate the optical super-microscope (OSM) - a superoscillation-based linear imaging system with far-field working and observation distances - which can image an object in real-time and with sub-diffraction resolution. With our proof-of-principle prototype we report a point spread function with a spot size clearly reduced from the diffraction limit, and demonstrate corresponding improvements in two-point resolution experiments. Harnessing a new understanding of superoscillations, based on antenna array theory, our OSM achieves far-field, sub-diffraction optical imaging of an object without the need for fine scanning, data post-processing or object pre-treatment. Hence the OSM can be used in a wide variety of imaging applications beyond the diffraction limit, including real-time imaging of moving objects.

摘要

光学显微镜受到光的衍射性质的基本分辨率限制。虽然目前亚衍射光学显微镜的解决方案涉及近场、非线性和精细扫描操作的组合,但我们在此提出并展示了基于超振荡的光学超微镜(OSM),这是一种具有远场工作和观察距离的线性成像系统,可以实时以亚衍射分辨率成像物体。通过我们的原理验证原型,我们报告了一个具有明显小于衍射极限的光斑尺寸的点扩散函数,并在两点分辨率实验中证明了相应的改进。利用基于天线阵列理论的对超振荡的新认识,我们的 OSM 实现了远场、亚衍射光学成像,无需精细扫描、数据后处理或物体预处理。因此,OSM 可以在远场之外的各种成像应用中使用,包括对移动物体的实时成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24d5/3634104/1a45e5785a72/srep01715-f1.jpg

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