Lopez Ximena, Goldfine Allison B, Holland William L, Gordillo Ruth, Scherer Philipp E
J Pediatr Endocrinol Metab. 2013;26(9-10):995-8. doi: 10.1515/jpem-2012-0407.
Accumulation of ceramides within tissues induces insulin resistance. Moreover, adiponectin exerts its beneficial metabolic effects at least partially through ceramide catabolism. We hypothesized that specific plasma ceramide subspecies are elevated in obese children and adolescents with type 2 diabetes (T2D), and that they inversely correlate with adiponectin and measures of insulin sensitivity. This was a cross-sectional study. Participants included 14 obese female subjects with T2D, ages 10-17, and 14 lean healthy controls of the same age and gender. Fasting plasma ceramide subspecies were measured by quantitative tandem mass spectrometry. Subjects with T2D had higher concentrations of C22:0 and C20:0 ceramides, with a 2-fold increase in C18:0 ceramide and C24:1 dihydroceramide (p<0.05). C22:0, C20:0 and C18:0 ceramide correlated with decreased adiponectin concentrations, increased HOMA-IR, BMI Z-score, triglyceride and fasting blood glucose concentrations (p<0.05). Plasma levels of C18:0, C20:0 and C22:0 ceramide, as well as C24:1 dihydroceramide, were elevated in obese female children and adolescents with T2D. This may be a reflection of tissue insulin resistance and could be a result of low adiponectin levels.
组织内神经酰胺的积累会诱发胰岛素抵抗。此外，脂联素至少部分地通过神经酰胺分解代谢发挥其有益的代谢作用。我们假设，特定的血浆神经酰胺亚型在患有2型糖尿病（T2D）的肥胖儿童和青少年中升高，并且它们与脂联素和胰岛素敏感性指标呈负相关。这是一项横断面研究。参与者包括14名年龄在10 - 17岁的患有T2D的肥胖女性受试者，以及14名年龄和性别相同的瘦的健康对照者。通过定量串联质谱法测量空腹血浆神经酰胺亚型。患有T2D的受试者C22:0和C20:0神经酰胺浓度较高，C18:0神经酰胺和C24:1二氢神经酰胺增加了2倍（p<0.05）。C22:0、C20:0和C18:0神经酰胺与脂联素浓度降低、HOMA-IR增加、BMI Z评分、甘油三酯和空腹血糖浓度相关（p<0.05）。患有T2D的肥胖女性儿童和青少年血浆中C18:0、C20:0和C22:0神经酰胺以及C24:1二氢神经酰胺水平升高。这可能反映了组织胰岛素抵抗，并且可能是脂联素水平低的结果。
