Shen Xueping, Feng Rui, Zhou Rui, Zhang Zhaoyang, Liu Kaiyong, Wang Sheng
School of Stomatology, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, China.
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Center for Scientific Research, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, China.
Metabolites. 2025 Mar 11;15(3):195. doi: 10.3390/metabo15030195.
Ceramide, a sphingolipid metabolite, has emerged as a key player in various physiological and pathological processes. Changes in ceramide levels are associated with the occurrence and development of various diseases, highlighting its potential as a biomarker of various clinical diseases. The biosynthesis and metabolism of ceramide are discussed, along with its functions in cell signaling, apoptosis, and inflammation. This study further examines the potential of ceramide as a biomarker for disease diagnosis and treatment. This article highlights the involvement of ceramide in several diseases, including cardiovascular diseases, dermatosis, cancer, neurodegenerative disorders and metabolic syndromes. For each disease, the potential of ceramide as a biomarker for disease diagnosis and prognosis is explored, and the feasibility of therapeutic strategies targeting ceramide metabolism are reviewed. Additionally, the challenges and future directions in the field of ceramide research are addressed. This review article provides an overview of the recent advances in understanding the role of ceramide in clinical diseases and its potential as a diagnostic and therapeutic tool.
神经酰胺是一种鞘脂代谢产物，已成为各种生理和病理过程中的关键参与者。神经酰胺水平的变化与各种疾病的发生和发展相关，凸显了其作为各种临床疾病生物标志物的潜力。本文讨论了神经酰胺的生物合成和代谢，以及它在细胞信号传导、细胞凋亡和炎症中的作用。本研究进一步探讨了神经酰胺作为疾病诊断和治疗生物标志物的潜力。本文重点介绍了神经酰胺与几种疾病的关联，包括心血管疾病、皮肤病、癌症、神经退行性疾病和代谢综合征。针对每种疾病，探讨了神经酰胺作为疾病诊断和预后生物标志物的潜力，并综述了针对神经酰胺代谢的治疗策略的可行性。此外，还讨论了神经酰胺研究领域的挑战和未来方向。这篇综述文章概述了在理解神经酰胺在临床疾病中的作用及其作为诊断和治疗工具的潜力方面的最新进展。
