Radiation Oncology, Emory University, Atlanta, Georgia, USA.
Am J Alzheimers Dis Other Demen. 2013 May;28(3):258-62. doi: 10.1177/1533317513481097.
The etiology of Alzheimer's disease (AD) is multifactorial involving both genetic and environmental factors. Apolipoprotein E (ApoE) gene plays a pivotal role in risk and age of onset of AD. Although it is broadly accepted that ApoE genotype is linked to the pathogenesis of AD, there are still controversial results regarding the association of ApoE levels in cerebrospinal fluid (CSF) with the occurrence of AD. Some studies have shown a positive correlation between CSF ApoE levels and AD, whereas others showed no link. In this study, we measured ApoE levels to assess the usefulness of CSF ApoE as a diagnostic marker of AD by comparing the levels in 3 patient groups and in control participants. No significant difference was observed in CSF ApoE concentrations between the patients with AD and the controls. So, it appears that CSF ApoE measurement does not offer any diagnostic advantage for AD.
阿尔茨海默病（AD）的病因是多因素的，涉及遗传和环境因素。载脂蛋白 E（ApoE）基因在 AD 的风险和发病年龄中起关键作用。尽管普遍认为 ApoE 基因型与 AD 的发病机制有关，但关于脑脊液（CSF）中 ApoE 水平与 AD 发生的相关性仍存在争议结果。一些研究表明 CSF ApoE 水平与 AD 呈正相关，而另一些研究则没有关联。在这项研究中，我们测量了 ApoE 水平，通过比较 3 组患者和对照组的水平来评估 CSF ApoE 作为 AD 诊断标志物的有用性。AD 患者和对照组之间 CSF ApoE 浓度没有显著差异。因此，CSF ApoE 测量似乎对 AD 没有任何诊断优势。
