Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke University, Magdeburg, Germany.
J Clin Pathol. 2013 Sep;66(9):819-22. doi: 10.1136/jclinpath-2013-201448. Epub 2013 Apr 23.
The interplay between gastric and intestinal transcription factors has an important impact on gastric carcinogenesis. We compared the gene expression of CDX1, CDX2, SOX2 and related downstream genes in tumour and tumour surrounding gastric tissue of 48 gastric cancer patients with 30 healthy controls. There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumour-distant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01). SOX2 was downregulated in tumour tissue compared to controls, whereas tumour-adjacent and tumour-distant mucosa showed intermediate SOX2 expression. Laurén type and Helicobacter pylori infection had no significant impact on expression of the transcription factors. Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia. The differential regulation of the gene expression of CDX1, CDX2 and SOX2 in patients with gastric cancer affects not only the tumour but also the non-neoplastic tumour-distant mucosa.
胃和肠转录因子之间的相互作用对胃癌的发生有重要影响。我们比较了 48 例胃癌患者肿瘤组织及其肿瘤周围胃组织与 30 例健康对照者的 CDX1、CDX2、SOX2 及相关下游基因的表达。肿瘤或肿瘤旁与肿瘤远隔黏膜之间 CDX1 和 CDX2 的基因表达无差异，但与对照组相比，这两种因子在癌症患者中表达明显升高（p<0.01）。与对照组相比，SOX2 在肿瘤组织中下调，而肿瘤旁和肿瘤远隔黏膜则显示中间 SOX2 表达。Laurén 分型和幽门螺杆菌感染对转录因子的表达没有显著影响。肠上皮化生时 CDX1 和 CDX2 的表达更高。胃癌患者 CDX1、CDX2 和 SOX2 基因表达的差异调节不仅影响肿瘤，还影响非肿瘤性肿瘤远隔黏膜。
