Ale O K, Ajuluchukwu J N, Oke D A, Mbakwem A C
Department of Medicine, College of Medicine,Lagos University Teaching Hospital, PMB 12003 Lagos. Nigeria.
West Afr J Med. 2013 Jan-Mar;32(1):57-61.
Increased QT dispersion (QTd) has been implicated as a marker of arrhythmogenesis and cardiac death. Paucity of literature on QTd in Nigeria necessitated an inquiry into QTd in adult hypertensive population. This study sought to: (i) compare the QTd values of adult hypertensive subjects with age and sex matched normotensive subjects and (ii)examine the relationship between QTd and left ventricular hypertrophy (LVH).
One hundred and fifty-one hypertensive patients and 101 age and sex-matched controls were recruited into this study. A resting 12- lead ECG was obtained from all subjects for determination of QTd and ECG LVH using Sokolow Lyon (SL) and Araoye's codes. Echocardiographic LVH was determined for 60 hypertensive subjects and 60 age/sex matched controls.
Hypertensive subjects had higher mean QTd than the controls (65.6 ± 28.1 ms vs 38.7 ± 11.3 ms, p< 0.0001). QTd of hypertensives with ECG LVH was significantly higher than those without ECG LVH (Araoye: 71.5 ± 22.0 ms vs 62.2 ± 24.1 ms, p = 0.02, SL; 72.0 ± 24.4 ms vs 61.6 ± 23.1 ms p = 0.009). Similarly the QTd of hypertensives with echocardiographic LVH (72.6 ± 21.3 ms) was higher than those without (60.1 ± 22.2 ms) but did not achieve statistical significance (p = 0.085).
Hypertension with or without ECG LVH is associated with significantly increased QTd. Echo-cardiographic LVH is associated with a non significant increase in QTd in hypertensive subjects.
QT离散度（QTd）增加被认为是心律失常发生和心源性死亡的一个标志。尼日利亚关于QTd的文献较少，因此有必要对成年高血压人群的QTd进行调查。本研究旨在：（i）比较成年高血压患者与年龄和性别匹配的正常血压者的QTd值；（ii）研究QTd与左心室肥厚（LVH）之间的关系。
151例高血压患者和101例年龄和性别匹配的对照者被纳入本研究。所有受试者均进行静息12导联心电图检查，以使用索科洛夫-里昂（SL）和阿拉奥耶标准测定QTd和心电图LVH。对60例高血压患者和60例年龄/性别匹配的对照者进行了超声心动图LVH测定。
高血压患者的平均QTd高于对照组（65.6±28.1毫秒对38.7±11.3毫秒，p<0.0001）。有心电图LVH的高血压患者的QTd显著高于无心电图LVH的患者（阿拉奥耶标准：71.5±22.0毫秒对62.2±24.1毫秒，p = 0.02；SL标准：72.0±24.4毫秒对61.6±23.1毫秒，p = 0.009）。同样，有超声心动图LVH的高血压患者的QTd（72.6±21.3毫秒）高于无超声心动图LVH的患者（60.1±22.2毫秒），但未达到统计学显著性（p = 0.085）。
有或无心电图LVH的高血压均与QTd显著增加有关。超声心动图LVH与高血压患者QTd的非显著性增加有关。
