Ale O K, Ajuluchukwu J N, Ok D A, Mbakwem A C
Department of Medicine, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria.
Cardiovasc J Afr. 2014 Mar-Apr;25(2):78-82. doi: 10.5830/CVJA-2014-010.
Prehypertension has been associated with target-organ damage. This study sought to determine the impact of prehypertension (PHT) on QT dispersion and left ventricular hypertrophy (LVH) in adult black Nigerians.
One hundred and one subjects with office blood pressure (BP) < 140/90 mmHg were categorised according to their office BP into normotensive (normal BP < 120/80 mmHg, n = 57) and prehypertensive (prehypertensive BP 120-139/80-89 mmHg, n = 44) groups. Echocardiography and electrocardiography (ECG) were performed on the subjects.
Thirty-four males aged 53.65 ± 16.33 years and 67 females aged 52.42 ± 12.00 years were studied. The mean QT interval dispersion (QT(d)) of the normotensive (38.96 ± 11.06 ms) and prehypertensive (38.41 ± 11.81 ms) groups were similar (p = 0.81). Prehypertensive subjects had higher left ventricular mass (LVM) (165.75 ± 33.21 vs 144.54 ± 35.55 g, p = 0.024), left ventricular mass index 1 (LVMI-1) (91.65 ± 16.84 vs 80.45 ± 18.65 g/m(2), p = 0.021) and left ventricular mass index 2 (LVMI-2) (54.96 ± 10.84 vs 47.51 ± 12.00 g/m(2.7), p = 0.017). QT(d) was independent of echocardiographic and electrocardiographic LVH (p > 0.05).
Compared with normotension, prehypertension is associated with higher LVM but similar QT(d). This suggests that structural remodelling precedes electrical remodelling in prehypertension.
高血压前期与靶器官损害有关。本研究旨在确定高血压前期（PHT）对成年尼日利亚黑人QT离散度和左心室肥厚（LVH）的影响。
101名诊室血压（BP）<140/90 mmHg的受试者根据其诊室血压分为正常血压组（正常BP<120/80 mmHg，n = 57）和高血压前期组（高血压前期BP 120 - 139/80 - 89 mmHg，n = 44）。对受试者进行了超声心动图和心电图（ECG）检查。
研究了34名年龄为53.65±16.33岁的男性和67名年龄为52.42±12.00岁的女性。正常血压组（38.96±11.06 ms）和高血压前期组（38.41±11.81 ms）的平均QT间期离散度（QT(d)）相似（p = 0.81）。高血压前期受试者的左心室质量（LVM）更高（165.75±33.21对144.54±35.55 g，p = 0.024），左心室质量指数1（LVMI - 1）（91.65±16.84对80.45±18.65 g/m²，p = 0.021）和左心室质量指数2（LVMI - 2）（54.96±10.84对47.51±12.00 g/m².⁷，p = 0.017）。QT(d)与超声心动图和心电图LVH无关（p>0.05）。
与正常血压相比，高血压前期与更高的LVM相关，但QT(d)相似。这表明在高血压前期结构重塑先于电重塑。
