Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland.
Prenat Diagn. 2013 Sep;33(9):856-62. doi: 10.1002/pd.4143. Epub 2013 May 16.
The goals of this study are to assess pregnancy outcome with increased nuchal translucency (NT) and to determine the risk of adverse pregnancy outcome in relation to the degree of increased NT.
All singleton pregnancies with increased NT at the first screening ultrasound examination referred to the Department of Fetal Medicine at the Helsinki University Central Hospital during 2002 to 2007 were included. Pregnancy outcomes and short-term outcomes of the newborns were recorded and analyzed.
Of the 1063 pregnancies, karyotype was normal in 834 (78%). The majority, 611 (73%), of euploid fetuses was in the lowest NT group (95th percentile--3.4 mm). Percentage of favorable outcome decreased from 92% in the lowest NT group (95th percentile--3.4 mm) to 18% in the highest NT group (≥6.5 mm). Structural defects or genetic disorders were observed in 74 (9%) of cases with normal karyotype, of which 43 (58%) resulted in live birth, 25 (34%) in termination of pregnancy, and 6 (8%) in miscarriage or perinatal death.
Even minimal (95th percentile--3.4 mm) increase in NT thickness is associated with adverse pregnancy outcome also in euploid fetuses.
本研究旨在评估颈项透明层（NT）增厚的妊娠结局，并确定与 NT 增厚程度相关的不良妊娠结局风险。
本研究纳入了 2002 年至 2007 年期间在赫尔辛基大学中央医院胎儿医学科进行首次超声筛查时 NT 增厚的所有单胎妊娠。记录并分析了妊娠结局和新生儿的短期结局。
在 1063 例妊娠中，834 例（78%）核型正常。大多数（611 例，73%）正常核型胎儿处于 NT 最低组（第 95 百分位-3.4mm）。在 NT 最低组（第 95 百分位-3.4mm），良好结局的比例为 92%，而在 NT 最高组（≥6.5mm）则降至 18%。在核型正常的 74 例中观察到结构缺陷或遗传异常，其中 43 例（58%）导致活产，25 例（34%）终止妊娠，6 例（8%）流产或围产儿死亡。
即使 NT 厚度仅略有增加（第 95 百分位-3.4mm），也与正常核型胎儿的不良妊娠结局相关。
