Hu Xi-Dong, Bao Yang-Yang, Zhou Shui-Hong, Yao Hong-Tian, Mao Jian-Ying, Ji Xue-Xian, Wu Xiao-Hong
Department of Otolaryngology, People's Hospital of Deqing County, Zhejiang, China.
J Int Med Res. 2013 Jun;41(3):777-84. doi: 10.1177/0300060513478089. Epub 2013 Apr 18.
To investigate the expression of interleukin (IL) 17A in Chinese patients with chronic rhinosinusitis (CRS) and analyse its correlation with clinical parameters.
Patients undergoing functional endoscopic sinus surgery and matched controls were included in this retrospective study. Clinical assessments (using a visual analogue scale of symptom severity, Johansson endoscopic score and Lund-Mackay computed tomography score) were performed preoperatively. Mucosal specimens were analysed for inflammatory infiltration and IL-17A expression, using immunohistochemistry.
In total, 40 patients undergoing functional endoscopic sinus surgery and 16 controls were included in the study. IL-17A levels were significantly higher in tissues from patients with CRS (with or without nasal polyps) than in control tissues. In CRS, IL-17A expression tended to be higher in tissues with infiltrating neutrophils than in those with infiltrating eosinophils, but this difference was not significant. IL-17A expression in CRS was positively correlated with symptom severity, endoscopic findings and radiological appearance.
Expression of IL-17A was higher in Chinese patients with CRS than in controls, and was associated with infiltrating inflammatory cells, symptom severity, endoscopic findings and radiological appearance. These findings suggest that IL-17A may play a role in CRS pathogenesis and remodelling of nasal polyps.
研究白细胞介素（IL）-17A在中国慢性鼻-鼻窦炎（CRS）患者中的表达，并分析其与临床参数的相关性。
本回顾性研究纳入了接受功能性鼻内镜鼻窦手术的患者及匹配的对照组。术前进行临床评估（采用症状严重程度视觉模拟量表、约翰松内镜评分和伦德-麦凯计算机断层扫描评分）。采用免疫组织化学方法分析黏膜标本的炎症浸润和IL-17A表达。
本研究共纳入40例接受功能性鼻内镜鼻窦手术的患者和16例对照组。CRS患者（伴或不伴鼻息肉）组织中的IL-17A水平显著高于对照组织。在CRS中，浸润中性粒细胞的组织中IL-17A表达往往高于浸润嗜酸性粒细胞的组织，但差异不显著。CRS中IL-17A表达与症状严重程度、内镜检查结果和影像学表现呈正相关。
中国CRS患者中IL-17A的表达高于对照组，且与炎症细胞浸润、症状严重程度、内镜检查结果和影像学表现相关。这些发现提示IL-17A可能在CRS发病机制和鼻息肉重塑中起作用。
