Tian Weiwei, Shen Jianping, Zhou Min, Yan Liangbin, Zhang Guocheng
Department for Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences, Jiangsu, P.R. China.
Lepr Rev. 2012 Dec;83(4):370-7.
To Study the incidence and clinical characteristics of dapsone hypersensitivity syndrome (DHS) among MDT-treated leprosy patients from 2006 to 2009 in China.
A retrospective survey was carried out throughout China using a specially designed questionnaire.
From 2006 to 2009, there were 63 new patients reported to have DHS with an incidence of 1.0%. Among these patients, 13 were complete types of DHS, the others were incomplete ones. The average age of patients with DHS was 38 years and the male to female ratio was 2.15. The average incubation period from taking dapsone to DHS onset was 32.8 days (2-6 weeks). There were 60 (95.2%) patients who presented with various skin lesions, 56 (88.9%) with fever, 40 (63.5%) with hepatic damage and 22 (34.9%) with lymphopathy. Seven patients died with a death rate of 11.1% among all patients with DHS.
DHS is a serious adverse event resulted from dapsone. It can occur in a small number of new leprosy patients treated with dapsone containing regimen. Some patients may die of DHS if not taking timely and adequate management. Therefore local doctors should pay an attention to DHS among leprosy patients newly treated with the dapsone-containing MDT regimen.
研究2006年至2009年中国接受多药联合治疗（MDT）的麻风病患者中氨苯砜超敏综合征（DHS）的发病率及临床特征。
采用专门设计的问卷在中国进行回顾性调查。
2006年至2009年，共报告63例新发生DHS的患者，发病率为1.0%。其中，13例为完全型DHS，其余为不完全型。DHS患者的平均年龄为38岁，男女比例为2.15。从服用氨苯砜至DHS发病的平均潜伏期为32.8天（2 - 6周）。有60例（95.2%）患者出现各种皮肤损害，56例（88.9%）发热，40例（63.5%）肝损害，22例（34.9%）有淋巴结病。7例患者死亡，在所有DHS患者中的死亡率为11.1%。
DHS是氨苯砜引起的严重不良事件。在少数接受含氨苯砜治疗方案的新麻风病患者中可能发生。部分患者若未及时进行充分治疗可能死于DHS。因此，当地医生应关注新接受含氨苯砜MDT方案治疗的麻风病患者中的DHS。
