Adwan Marwan H
Division of Rheumatology, Department of Medicine, The University of Jordan, Queen Rania Street, Amman, 11942, Jordan.
Curr Rheumatol Rep. 2017 Jan;19(1):3. doi: 10.1007/s11926-017-0626-z.
The purpose of the review is to summarise the various drugs used in rheumatology practice implicated in the causation of DRESS syndrome.
The most commonly reported drugs are allopurinol, sulfasalazine and minocycline, which pose a very high risk for DRESS syndrome development, followed by strontium ranelate and dapsone. Other, less commonly reported, drugs include leflunomide, hydroxychloroquine, non-steroidal anti-inflammatory drugs, febuxostat, bosentan and solcitinib. Reaction to some drugs is strongly associated with certain HLA alleles, which may be used to screen patients at risk of serious toxicity. DRESS syndrome is a serious reaction to many drugs used in rheumatic diseases, with a potentially fatal outcome and needs to be considered in any patient started on these medications who presents with a rash, fever and eosinophilia, sometimes with internal organ involvement.
本综述旨在总结在风湿病治疗中使用的、与药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征病因相关的各类药物。
最常报告的药物是别嘌醇、柳氮磺吡啶和米诺环素，它们引发DRESS综合征的风险非常高，其次是雷奈酸锶和氨苯砜。其他较少报告的药物包括来氟米特、羟氯喹、非甾体抗炎药、非布司他、波生坦和索拉替尼。对某些药物的反应与特定的人类白细胞抗原（HLA）等位基因密切相关，这可用于筛查有严重毒性风险的患者。DRESS综合征是对许多用于治疗风湿性疾病的药物的严重反应，可能导致致命后果，对于任何开始使用这些药物且出现皮疹、发热和嗜酸性粒细胞增多（有时伴有内脏器官受累）的患者都需要考虑到这一点。
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